Niazimicin: A thiocarbamate glycoside from Moringa oleifera Lam. seeds with a novel neuroprotective activity
Corresponding Author
Eman M. Abdelsayed
School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
Correspondence
Eman M. Abdelsayed, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, 11578 Cairo, Egypt.
Email: [email protected] and [email protected]
Contribution: Conceptualization, Investigation, Resources, Writing - original draft
Search for more papers by this authorDalia Medhat
Department of Medical Biochemistry, National Research Centre, Giza, Egypt
Contribution: Formal analysis, Methodology, Writing - review & editing
Search for more papers by this authorYasmine M. Mandour
School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
Contribution: Formal analysis, Software, Writing - original draft
Search for more papers by this authorRasha S. Hanafi
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
Contribution: Project administration, Supervision
Search for more papers by this authorAmira Abdel Motaal
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Contribution: Conceptualization, Supervision, Writing - review & editing
Search for more papers by this authorCorresponding Author
Eman M. Abdelsayed
School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
Correspondence
Eman M. Abdelsayed, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, 11578 Cairo, Egypt.
Email: [email protected] and [email protected]
Contribution: Conceptualization, Investigation, Resources, Writing - original draft
Search for more papers by this authorDalia Medhat
Department of Medical Biochemistry, National Research Centre, Giza, Egypt
Contribution: Formal analysis, Methodology, Writing - review & editing
Search for more papers by this authorYasmine M. Mandour
School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
Contribution: Formal analysis, Software, Writing - original draft
Search for more papers by this authorRasha S. Hanafi
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
Contribution: Project administration, Supervision
Search for more papers by this authorAmira Abdel Motaal
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Contribution: Conceptualization, Supervision, Writing - review & editing
Search for more papers by this authorAbstract
Moringa oleifera (MO) known as the miracle tree is a famous nutritional source in many countries. In this study, the neuroprotective activity of MO seeds was investigated. Fractions of the 70% ethanol seed extract of MO were injected at a dose of 250 mg kg−1 day−1 to albino rats for 15 days, after-which induction of dementia was done using 100 mg/kg AlCl3 over 30 days. Results revealed that all fractions ameliorated the effects of AlCl3 where methylene chloride and ethyl acetate fractions, containing the major bioactive compound niazimicin (NZ), showed the best activities. Biological investigations proved NZ to be a highly potent neuroprotective drug lead as a first report, by causing a decrease in the levels of malondialdehyde, cholinesterase, nitric oxide (NO) and amyloid β by 47%, 34%, 53% and 59%, respectively, and increasing glutathione levels by 54%. Molecular docking studies suggested NZ neuroprotective effects to be mediated by inhibition of caspase-3 and inducible nitric oxide synthase enzymes.
Practical applications
The current findings present the neuroprotective effect of Moringa oleifera seeds consumed as a food supplement and in daily diet. In addition, niazimicin is a promising lead for the development of novel agents against Alzheimer’s disease as seen by the reported results.
CONFLICTS OF INTEREST
The author declares that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.
Supporting Information
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