Goldenberry (Physalis peruviana) Juice Rich in Health-Beneficial Compounds Suppresses High-Cholesterol Diet-Induced Hypercholesterolemia in Rats
Corresponding Author
Mohamed Fawzy Ramadan
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519 Egypt
Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742
Corresponding author. TEL: 2-055-2320282 or 2-0129782424; FAX: 2-055-2287567 or 2-055-2345452; EMAIL: [email protected]; [email protected]Search for more papers by this authorNesma Ali Hassan
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519 Egypt
Search for more papers by this authorRafaat M. Elsanhoty
Department of Industrial Biotechnology, Branch of Food and Dairy Biotechnology, Institute of Genetic Engineering and Biotechnology, Menoufia University, Zagazig, Egypt
Present address: Department of Food Science and Human Nutrition, Faculty of Agriculture and Veterinary Medicine, Qassim University, Kingdom of Saudi Arabia.Search for more papers by this authorMahmoud Z. Sitohy
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519 Egypt
Search for more papers by this authorCorresponding Author
Mohamed Fawzy Ramadan
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519 Egypt
Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742
Corresponding author. TEL: 2-055-2320282 or 2-0129782424; FAX: 2-055-2287567 or 2-055-2345452; EMAIL: [email protected]; [email protected]Search for more papers by this authorNesma Ali Hassan
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519 Egypt
Search for more papers by this authorRafaat M. Elsanhoty
Department of Industrial Biotechnology, Branch of Food and Dairy Biotechnology, Institute of Genetic Engineering and Biotechnology, Menoufia University, Zagazig, Egypt
Present address: Department of Food Science and Human Nutrition, Faculty of Agriculture and Veterinary Medicine, Qassim University, Kingdom of Saudi Arabia.Search for more papers by this authorMahmoud Z. Sitohy
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519 Egypt
Search for more papers by this authorAbstract
enGoldenberries (Physalis peruviana) are a promising exotic fruit that could be a subject of many novel foods. No reports are available on the effect of administration of goldenberries on different aspects of blood profile in experimental animals. The objective of this study was to investigate the effect of feeding goldenberry juice on hypercholesterolemia by analyzing the changes in the blood profile of high-cholesterol diet (HCD)-fed rats. The chemical composition and antiradical properties of juice were determined. Generally, rats fed with goldenberry juice showed lower levels of total cholesterol, total triacylglycerol and total low-density lipoprotein cholesterol, as well as higher levels of high-density lipoprotein cholesterol in comparison with animals fed with HCD and cholesterol-free diet. Juice administration induced a decrease in the activity of glutamic pyruvic transaminase compared with the positive control group after 2 months of administration. There was a remarkable decrease in total serum protein, albumin and globulin for groups treated with goldenberry juice. Histological examination of the liver and kidney were also conducted. The results demonstrated that consumption of goldenberry juice may provide beneficial effects on reversing HCD-associated detrimental changes.
Practical Applications
frThe administration of goldenberry juice has a profound influence on the metabolism of lipids and positively affects the blood profile of rats fed with a high-cholesterol diet (HCD). The results suggest that goldenberry juice has significant hypocholesterolemic activities. In addition, goldenberry juice seems to protect the liver in response to oxidative stress (probably via the elevation of antioxidant enzymes levels) as well as alleviate the magnitude of fatty liver development in response to HCD. Therefore, goldenberry juice with high antioxidant potential could be helpful for patients suffering from coronary atherosclerosis.
References
- AOAC. 1995. Official Methods of Analysis, 15th Ed., Association of Official Analytical Chemists, Washington, DC.
-
Belitz, H.D. and Grosch, W. 1999. Food Chemistry, Springer-Verlag, Berlin, Germany.
10.1007/978-3-662-07281-3 Google Scholar
- Bors, W., Heller, W., Michel, C. and Saran, M. 1990. Flavonoids as antioxidants: Determination of radical scavenging efficiencies. Methods Enzymol. 186, 343–355.
- Charleux, J.L. 1996. Beta-carotene, vitamin C, and vitamin E: The protective micronutrients. Nutr. Rev. 54, S109–S114.
- Chen, Z.Y., Ma, K.Y., Peng, C. and Zuo, Y. 2011. Role and classification of cholesterol-lowering functional foods. J. Funct. Foods 3, 61–69.
- Choi, H.S., Do, K.M., Park, Y.B., Jeon, S.M., Jeong, T., Lee, Y.K., Lee, M.K. and Bok, S.H. 2001. Effect of naringenin supplementation on cholesterol metabolism and antioxidant status on rats fed high cholesterol with different levels of vitamin E. Ann. Nutr. Metab. 45, 193–201.
- Cook, N.C. and Samman, S. 1996. Flavonoids – chemistry, metabolism, cardioprotective effects, and dietary sources. J. Nutr. Biochem. 7, 66–76.
- Coudon, B. and Bouige, D. 1973. Automatic method for determination of total serum lipids, using the sulfophosphovanillic reaction. Ann. Biol. Clin. (Paris) 31, 3–7.
- Craig, W.J. 1999. Health-promoting properties of common herbs. Am. J. Clin. Nutr. 70, 491–499.
- Cunnane, S.C., Gangali, S., Menard, A.C., Liede, M.J., Hamedeh, Z.Y., Chen, T.M., Wolever, T.M. and Jenkins, D.J.A. 1993. High α-linolenic acid flaxseed (Linum usitatissimum). Some nutritional properties in humans. Br. J. Nutr. 69, 443–453.
- Daher, C.F., Baroody, F.G. and Baroody, M.G. 2006. Effect of Urtica dioica extract intake upon blood lipid profile in the rats. Fitoterapia 77, 183–188.
- Deepa, P.R. and Varalakshmi, P. 2005. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin. Chim. Acta 355, 119–130.
- Demacker, A.G., Hijmans, B.G., Brenninkmeijer, A.P., Jansen, J.S. and van't Laar, A. 1984. Five methods for determining low-density lipoprotein cholesterol compared. Clin. Chem. 30, 1797–1800.
- Doumas, B.T., Watson, W.A. and Biggs, H.G. 1971. Albumin standards and the measurement of serum albumin with bromocresol green. Clin. Chim. Acta 31, 87–96.
- Feoli, A.M., Roehrig, C., Rotta, L.N., Kruger, A.H., Souza, K.B., Kesseler, A.M., Renz, S.V., Brusque, A.M., Souza, D.O. and Perry, M.L.S. 2003. Serum and liver lipids in rats and chicks fed with diets containing different oils. Nutrition 19, 789–793.
- Fossati, P. and Prencipe, L. 1982. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 28, 2077–2080.
- Guan, L., Chung, H.Y. and Chen, Z.Y. 2011. Comparison of hypocholesterolemic activity of tea seed oil with commonly used vegetable oils in hamsters. J. Food Biochem. 35, 859–876.
- Gurrieri, S., Miceli, L., Lanza, M., Tomaselli, F., Bonomo, R.P. and Rizzarelli, E. 2000. Chemical characterization of sicilian prickly pear (Opuntia ficus indica) and perspective for the storage of its juice. J. Agric. Food Chem. 48, 5424–5431.
- Häkkinen, S.H., Kärenlampi, S.O., Heinonen, I.M., Mykkänen, H.M. and Riitta, A.T. 1999. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J. Agric. Food Chem. 47, 2274–2279.
- Henry, R.J. 1964. Clinical Chemistry, p. 181, Harper and Row Publisher, New York, NY.
- Jones, P.J., Ntanios, F.Y., Raeini-Sarjaz, M. and Vanstone, C. 1999. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am. J. Clin. Nutr. 69, 1144–1150.
- Kastelein, J.J. 2007. Refocusing on use of cholesteryl ester transfer protein inhibitors. Am. J. Cardiol. 100, S47–S52.
- Khera, A.V. and Rader, D.J. 2010. Future therapeutic directions in reverse cholesterol transport. Curr. Atheroscler. Rep. 12, 73–81.
- Kurowska, E.M., Spence, J.D., Jordan, J., Wetmore, S., Freeman, D.J., Piché, L.A. and Serratore, P. 2000. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am. J. Clin. Nutr. 72, 1095–1100.
- Leys, D., Deplanque, D., Mounier-Vehier, C., Mackowiak-Cordoliani, M.A., Lucas, C. and Bordet, R. 2002. Stroke prevention: Management of modifiable vascular risk factors. J. Neurol. 249, 507–517.
- Mayorga, H., Knapp, H., Winterhalter, P. and Duque, C. 2001. Glycosidically bound flavor compounds of cape gooseberry (Physalis peruviana L.). J. Agric. Food Chem. 49, 1904–1908.
- McCain, R. 1993. Goldenberry, passionfruit and white sapote: Potential fruits for cool subtropical areas. In New Crops, ( J. Janick and J.E. Simon, eds.) pp. 479–486, Wiley & Sons, New York, NY.
- McPherson, P.A., Young, I.S. and McEneny, J. 2007. A dual role for lecithin: Cholesterol acyltransferase (EC 2.3.1.43) in lipoprotein oxidation. Free Radic. Biol. Med. 43, 1484–1493.
- Meyer, A.S., Yi, O.S., Pearson, D.A., Waterhouse, A.L. and Frankel, E.N. 1995. Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). J. Agric. Food Chem. 45, 1638–1643.
- Miller, G.J. and Miller, N.E. 1997. Plasma HDL Concentration and Development of IHD. Heart and Stroke, Statistical Update, pp. 16–21, University Press, Dallas, TX.
- Miller, N.J. and Rice-Evans, C.A. 1997. The relative contributions of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and blackcurrant drink. Food Chem. 60, 331–337.
- Morton, J.F. 1987. Cape gooseberry. In Fruits of Warm Climates, ( J.F. Morton, ed.) pp. 430–434, Creative Resource Systems Inc., Winterville, NC.
- Nagai, T. and Inoue, R. 2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem. 84, 181–186.
- Patton, C.J. and Crouch, S.R. 1977. Enzymatic determination of urea. Anal. Chem. 49, 469–472.
- Penumathsa, S.V., Thirunavukkarasu, M., Koneru, S., Juhasz, B., Zhan, L. and Pant, R. 2007. Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J. Mol. Cell. Cardiol. 42, 508–516.
- Popenoe, H., King, S.R., Leon, J. and Kalinowski, L.S. 1990. Goldenberry (cape gooseberry). In Lost Crops of the Incas, Little-known Plants of the Andes with Promise for Worldwide Cultivation, ( National Research Council, ed.) pp. 241–252, National Academy Press, Washington, DC.
- Ramadan, M.F. 2011. Bioactive phytochemicals, nutritional value, and functional properties of cape gooseberry (Physalis peruviana): An overview. Food Res. Int. 44, 1830–1836.
- Ramadan, M.F. and Mörsel, J.-T. 2003. Oil goldenberry (Physalis peruviana L.). J. Agric. Food Chem. 51, 969–974.
- Ramadan, M.F. and Mörsel, J.-T. 2004. Goldenberry: A novel fruit source of fat soluble bioactives. Inform 15, 130–131.
- Ramadan, M.F. and Mörsel, J.-T. 2007. Impact of enzymatic treatment on chemical composition, physicochemical properties and radical scavenging activity of goldenberry (Physalis peruviana L.) juice. J. Sci. Food Agric. 87, 452–460.
- Ramadan, M.F. and Mörsel, J.-T. 2009. Oil extractability from enzymatically-treated goldenberry (Physalis peruviana L.) pomace: Range of operational variables. Int. J. Food Sci. Technol. 44, 435–444.
- Ramadan, M.F., Sitohy, M.Z. and Mörsel, J.-T. 2008a. Solvent and enzyme-aided aqueous extraction of goldenberry (Physalis peruviana L.) pomace oil: Impact of processing on composition and quality of oil and meal. Eur. Food Res. Technol. 226, 1445–1458.
- Ramadan, M.F., Amer, M.M.A. and Awad, A. 2008b. Coriander (Coriandrum sativum L.) seed oil improves plasma lipid profile in rats fed diet containing cholesterol. Eur. Food Res. Technol. 227, 1173–1182.
- Ramadan, M.F., Kinni, S.G., Seshagiri, M. and Mörsel, J.-T. 2010. Fat-soluble bioactives, fatty acid profile and radical scavenging activity of Semecarpus anacardium seed oil. J. Am. Oil Chem. Soc. 87, 885–894.
- Ratcliffe, N.A. 1982. Practical Illustrated Histology, pp. 24–37, Macmillan, London, U.K.
- Reinhold, J.G. 1953. Standard Methods in Clinical Chemistry, Vol. I ( M. Reiner, ed.) p. 88, Academic Press, New York, NY.
- Reitman, S. and Frankel, S. 1957. Determination of serum glutamate oxaloacetate and glutamate pyruvate transaminases. Am. J. Clin. Pathol. 28, 56–60.
- Richmond, W. 1973. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem. 19, 1350–1356.
- Riemersma, R.A. 2001. The demise of the n-6 to n-3 fatty acid ratio? A dossier. Eur. J. Lipid Sci. Technol. 103, 372–373.
- Stocker, R.M. and Keaney, J.F. 2004. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84, 1381–1478.
- Strik, B.C. 2007. Berry crops: Worldwide area and production systems. In Berry Fruit, Value-added Products for Health Promotion ( Y. Zhao, ed.) CRC Press, Boca Raton, FL. ISBN-10: 0-8493-5802-7.
- Vijaimohan, K., Jainu, M., Sabitha, K.E., Subramaniyam, S., Anandhan, C. and Shyamala Devi, C.S. 2006. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. Life Sci. 79, 448–454.
- Wang, T., Hicks, K.B. and Moreau, R. 2002. Antioxidant activity of phytosterols, oryzanol and other phytosterols conjugates. J. Am. Oil Chem. Soc. 79, 1201–1206.
- Wasan, K.M., Najafi, S., Wong, J., Kwong, M. and Pritchard, P.H. 2001. Assessing plasma lipid levels, body weight, and hepatic and renal toxicity following chronic oral administration of a water-soluble phytostanol compound, FM-VP4, to gerbils. J. Pharmacol. Sci. 4, 228–234.
-
Zhao, Y. 2007. Berry Fruit, Value-added Products for Health Promotion, CRC Press, Boca Raton, FL.
10.1201/9781420006148 Google Scholar
