Clear Cell Neoplasm in Salivary Gland FNA? Maybe It’s From Kidney!
Isabella Sorice
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorAnna Maria Carillo
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorMaria Salatiello
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorCaterina De Luca
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorRosa Maria Di Crescenzo
Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorVincenzo Damiano
Department of Oncology and Hematology, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorGiovanni Dell’Aversana Orabona
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorElena Vigliar
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorCorresponding Author
Giancarlo Troncone
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Correspondence:
Giancarlo Troncone ([email protected])
Search for more papers by this authorClaudio Bellevicine
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorIsabella Sorice
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorAnna Maria Carillo
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorMaria Salatiello
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorCaterina De Luca
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorRosa Maria Di Crescenzo
Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorVincenzo Damiano
Department of Oncology and Hematology, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorGiovanni Dell’Aversana Orabona
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorElena Vigliar
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorCorresponding Author
Giancarlo Troncone
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Correspondence:
Giancarlo Troncone ([email protected])
Search for more papers by this authorClaudio Bellevicine
Department of Public Health, University of Naples “Federico II”, Naples, Italy
Search for more papers by this authorGraphical Abstract
This article reports a rare case of metastatic clear cell renal cell carcinoma presenting as a parotid gland mass, clinically and cytologically mimicking a primary salivary gland neoplasm. It underscores the diagnostic value of integrating cytological evaluation with clinical history and immunocytochemical profiling.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
References
- 1T. Woods, S. Fitzpatrick, D. Cohen, M. Islam, and I. Bhattacharyya, “Metastatic Renal Cell Carcinoma to the Salivary Gland: A Case Report and Review of the Literature,” Medicina Oral, Patología Oral y Cirugía Bucal 22, no. 3 (2017): 276–281, https://doi.org/10.4317/medoral.21570.
- 2H. Majewska, A. Skálová, K. Radecka, et al., “Renal Clear Cell Carcinoma Metastasis to Salivary Glands—A Series of 9 Cases: Clinico-Pathological Study,” Polish Journal of Pathology 67, no. 1 (2016): 39–45, https://doi.org/10.5114/pjp.2016.59475.
- 3U. Capitanio, K. Bensalah, A. Bex, et al., “Epidemiology of Renal Cell Carcinoma,” European Urology 75, no. 1 (2019): 74–84, https://doi.org/10.1016/J.EURURO.2018.08.036.
- 4S. Gupta, K. H. A. Alruwaili, R. L. O. Escobedo, et al., “Renal Cell Carcinoma Metastasizing to Salivary Glands: Systematic Review,” National Journal of Maxillofacial Surgery 15, no. 1 (2024): 3–17, https://doi.org/10.4103/njms.njms_79_23.
- 5Y. Morita, K. Kashima, M. Suzuki, et al., “Differential Diagnosis Between Oral Metastasis of Renal Cell Carcinoma and Salivary Gland Cancer,” Diagnostics 11 (2021): 506, https://doi.org/10.3390/diagnostics.
- 6F. Higuera, L. A. Boccalatte, M. J. Labanca, A. J. del Valle, J. J. Larrañaga, and M. F. Figari, “Renal Clear Cell Carcinoma Metastasis to Submandibular Gland: Case Report and Review of the Literature,” Journal of Surgical Case Reports 2018, no. 10 (2018): rjy261, https://doi.org/10.1093/jscr/rjy261.
- 7M. Balaban, V. S. Dogruyol, I. S. Idilman, O. Unal, and A. Ipek, “Renal Cell Carcinoma Metastasis to Ipsilateral Parotid and Submandibular Glands: Report of a Case With Sonoelastographic Findings,” Polish Journal of Radiology 81 (2016): 17–20, https://doi.org/10.12659/PJR.895430.
- 8S. M. Moudouni, M. Tligui, J. D. Doublet, F. Haab, B. Gattegno, and P. Thibault, “Late Metastasis of Renal Cell Carcinoma to the Submaxillary Gland 10 Years After Radical Nephrectomy,” International Journal of Urology 13, no. 4 (2006): 431–432, https://doi.org/10.1111/J.1442-2042.2006.01318.X.
- 9H. V. Prajapati, R. Shreevats, S. Gupta, H. Sandhu, J. Kaur, and J. Kaur, “Renal Cell Carcinoma Metastasizing to Oral Soft Tissues: Systematic Review,” Avicenna Journal of Medicine 14, no. 2 (2024): 75–109, https://doi.org/10.1055/s-0044-1,782,202.
- 10L. Xuan, S. Wang, J. Wei, J. Yuan, and H. Liu, “Clinicopathological and Molecular Study of 10 Salivary Gland Clear Cell Carcinomas, With Emphasis on Rare Cases With High Grade Transformation and Occurring in Uncommon Sites,” Diagnostic Pathology 17 (2022): 18, https://doi.org/10.1186/s13000-022-01200-z.
- 11C. De Luca, R. Sgariglia, M. Nacchio, et al., “Rapid On-Site Molecular Evaluation in Thyroid Cytopathology: A Same-Day Cytological and Molecular Diagnosis,” Diagnostic Cytopathology 48, no. 4 (2020): 300–307, https://doi.org/10.1002/DC.24378.
- 12A. Skalova, I. Leivo, H. Hellquist, et al., “Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge,” Advances in Anatomic Pathology 29, no. 4 (2022): 217–226, https://doi.org/10.1097/PAP.0000000000000339.
