Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature
Corresponding Author
Calies Menard-Katcher
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Correspondence
Calies Menard-Katcher, Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, 13123 E 16th Ave, Aurora, CO 80045, USA.
Email: [email protected]
Search for more papers by this authorCuining Liu
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, Colorado, USA
Search for more papers by this authorMatthew D. Galbraith
Department of Pharmacology, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Search for more papers by this authorTaylor Benson
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Department of Biology, Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland
Search for more papers by this authorCassandra Burger
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorDevin Dobias
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorLeigha Larsen
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorCarol O'Brien
Department of Biology, Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland
Search for more papers by this authorLisa A. Spencer
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorGlenn T. Furuta
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorJoanne C. Masterson
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Department of Biology, Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland
Search for more papers by this authorCorresponding Author
Calies Menard-Katcher
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Correspondence
Calies Menard-Katcher, Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, 13123 E 16th Ave, Aurora, CO 80045, USA.
Email: [email protected]
Search for more papers by this authorCuining Liu
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, Colorado, USA
Search for more papers by this authorMatthew D. Galbraith
Department of Pharmacology, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Search for more papers by this authorTaylor Benson
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Department of Biology, Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland
Search for more papers by this authorCassandra Burger
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorDevin Dobias
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorLeigha Larsen
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorCarol O'Brien
Department of Biology, Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland
Search for more papers by this authorLisa A. Spencer
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorGlenn T. Furuta
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Search for more papers by this authorJoanne C. Masterson
Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA
Department of Biology, Allergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland
Search for more papers by this author
Supporting Information
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|---|---|
| all15557-sup-0001-AppendixS1.pdfapplication/pdf: .pdf, 222 KB |
Appendix S1 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
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- 4Shoda T, Wen T, Caldwell JM, et al. Loss of endothelial TSPAN12 promotes Fibrostenotic eosinophilic esophagitis via endothelial cell-fibroblast crosstalk. Gastroenterology. 2022; 162: 439-453. doi:10.1053/j.gastro.2021.10.016
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- 6Manresa MC, Chiang AWT, Kurten RC, et al. Increased production of LIGHT by T cells in eosinophilic esophagitis promotes differentiation of esophageal fibroblasts toward an inflammatory phenotype. Gastroenterology. 2020; 159: 1778-1792 e1713. doi:10.1053/j.gastro.2020.07.035
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