High fractional exhaled nitric oxide levels may predict short-term worsening of respiratory oscillometry in asthma
Yoshinari Endo
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
Search for more papers by this authorCorresponding Author
Toshihiro Shirai
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
Correspondence
Toshihiro Shirai, MD, PhD, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka 420-8527, Japan.
Email: [email protected]
Search for more papers by this authorKeita Hirai
Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
Laboratory of Clinical Pharmacogenomics, Shizuoka General Hospital, Shizuoka, Japan
Search for more papers by this authorTaisuke Akamatsu
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
Search for more papers by this authorYoshinari Endo
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
Search for more papers by this authorCorresponding Author
Toshihiro Shirai
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
Correspondence
Toshihiro Shirai, MD, PhD, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka 420-8527, Japan.
Email: [email protected]
Search for more papers by this authorKeita Hirai
Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
Laboratory of Clinical Pharmacogenomics, Shizuoka General Hospital, Shizuoka, Japan
Search for more papers by this authorTaisuke Akamatsu
Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
Search for more papers by this authorFunding information
None.
CONFLICT OF INTEREST
The authors have nothing to disclose.
Supporting Information
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|---|---|
| all14484-sup-0001-Supinfo.docxWord document, 14.9 KB | Supplementary Material |
| all14484-sup-0002-FigE1.tiffTIFF image, 167.8 KB | Supplementary Material |
| all14484-sup-0003-TableE1-E3.docxWord document, 21.9 KB | Supplementary Material |
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REFERENCES
- 1Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011; 184(5): 602-615.
- 2Matsunaga K, Hirano T, Oka A, Ito K, Edakuni N. Persistently high exhaled nitric oxide and loss of lung function in controlled asthma. Allergol Int. 2016; 65(3): 266-271.
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- 4 Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2015. www.ginasthma.org
- 5Dweik RA, Sorkness RL, Wenzel S, et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med. 2010; 181(10): 1033-1041.
- 6King GG, Bates J, Berger KI, et al. Technical standards for respiratory oscillometry. Eur Respir J. 2020; 55(2): 1900753.
- 7Shirai T, Mori K, Mikamo M, et al. Respiratory mechanics and peripheral airway inflammation and dysfunction in asthma. Clin Exp Allergy. 2013; 43(5): 521-526.
- 8Michils A, Haccuria A, Michiels S, Van Muylem A. Airway calibre variation is a major determinant of exhaled nitric oxide’s ability to capture asthma control. Eur Respir J. 2017; 50(2): 1700392.
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