High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level (Small 6/2023)
Graphical Abstract
High-Throughput Cellular Heterogeneity
In article number 2206754, Yu-Chih Chen and co-workers present a microfluidic cell migration platform that coordinates robotic liquid handling and computer vision for rapidly quantifying individual cellular motility. The high-throughput single-cell screening experiments reveal that many compounds inhibit migration of most cells while leaving fast-moving subpopulations unaffected. They further investigate dynamic cell movement and discover synergistic drug combinations that overcome the resistance of fast-moving subpopulations.