Volume 19, Issue 6 2370035
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A Multilayered Mesoporous Gold Nanoarchitecture for Ultraeffective Near-Infrared Light-Controlled Chemo/Photothermal Therapy for Cancer Guided by SERS Imaging (Small 6/2023)

Bohan Yin

Bohan Yin

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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Willis Kwun Hei Ho

Willis Kwun Hei Ho

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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Xinyue Xia

Xinyue Xia

Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, 999077 China

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Cecilia Ka Wing Chan

Cecilia Ka Wing Chan

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong, 999077 China

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Qin Zhang

Qin Zhang

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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Yip Ming Ng

Yip Ming Ng

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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Ching Ying Katherine Lam

Ching Ying Katherine Lam

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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James Chung Wai Cheung

James Chung Wai Cheung

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

Research Institute for Sports Science and Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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Jianfang Wang

Jianfang Wang

Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, 999077 China

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Mo Yang

Mo Yang

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

Research Institute for Sports Science and Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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Siu Hong Dexter Wong

Siu Hong Dexter Wong

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

Research Institute for Sports Science and Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, 999077 China

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First published: 08 February 2023

Graphical Abstract

Chemo/Photothermal Therapy for Cancer Guided by SERS Imaging

In article number 2206762, Mo Yang, Siu Hong Dexter Wong, and co-workers develop a multilayered mesoporous gold nanoarchitecture labeled with Raman reporters for ultraeffective surface-enhanced Raman scattering (SERS) imaging-guided synergistic therapy toward cancer. This nanoplatform enables efficient xenograft tumor model targeting with sensitive SERS imaging in vitro and in vivo for identifying the tumor cells and optimal therapeutic time point, thereby achieving the highest therapeutic outcome of noninvasive near-infrared triggered photothermal therapy and hyperthermia enhanced chemotherapy.

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