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Influenza virus neuraminidase: Structure, antibodies, and inhibitors
P.M. Colman,
Corresponding Author
P.M. Colman
Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria, Australia 3052
Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria, Australia 3052Search for more papers by this authorP.M. Colman,
Corresponding Author
P.M. Colman
Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria, Australia 3052
Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria, Australia 3052Search for more papers by this authorAbstract
The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.
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