Journal of Polymer Science Part A: Polymer Chemistry

Article

Self-assembly of thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) micelles for drug delivery

Corresponding Author

Guiying Li

[email protected]

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

College of Chemistry and Materials Science, Ludong University, Yantai 264025, ChinaSearch for more papers by this author

Sen Song,

Sen Song

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

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Lei Guo,

Lei Guo

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

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Songmei Ma,

Songmei Ma

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

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Guiying Li,

Corresponding Author

Guiying Li

[email protected]

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

College of Chemistry and Materials Science, Ludong University, Yantai 264025, ChinaSearch for more papers by this author

Sen Song,

Sen Song

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

Search for more papers by this author

Lei Guo,

Lei Guo

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

Search for more papers by this author

Songmei Ma,

Songmei Ma

College of Chemistry and Materials Science, Ludong University, Yantai 264025, China

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First published: 17 June 2008

https://doi.org/10.1002/pola.22831

Citations: 133

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Abstract

Self-assembled thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) (PAA-b-PNIPAM) micelles for entrapment and release of doxorubicin (DOX) was described. Block copolymer PAA-b-PNIPAM associated into core-shell micelles in aqueous solution with collapsed PNIPAM block or protonated PAA block as the core on changing temperature or pH. Complexation of DOX with PAA-b-PNIPAM triggered by the electrostatic interaction and release of DOX from the complexes due to the changing of pH or temperature were studied. Complex micelles incorporated with DOX exhibited pH-responsive and thermoresponsive drug release profile. The release of DOX from micelles was suppressed at pH 7.2 and accelerated at pH 4.0 due to the protonation of carboxyl groups. Furthermore, the cumulative release of DOX from complex micelles was enhanced around LCST ascribed to the structure deformation of the micelles. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 5028–5035, 2008

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REFERENCES AND NOTES

1 Riess, G. Prog Polym Sci 2003, 28, 1107–1170.
10.1016/S0079-6700(03)00015-7
CAS Web of Science® Google Scholar
2 Gohy, J. F. Adv Polym Sci 2005, 190, 65–136.
10.1007/12_048
CAS Web of Science® Google Scholar
3 Lo, C.-L.;Huang, C.-K.;Lin, K.-M.;Hsiue, G.-H. Biomaterials 2007, 28, 1225–1235.
10.1016/j.biomaterials.2006.09.050
CAS PubMed Web of Science® Google Scholar
4 Han, H. D.;Shin, B. C.;Choi, H. S. Eur J Pharm Biopharm 2006, 62, 110–116.
10.1016/j.ejpb.2005.07.006
CAS PubMed Web of Science® Google Scholar
5 Yoo, H. S.;Park, T. G. J Controlled Release 2001, 70, 63–70.
10.1016/S0168-3659(00)00340-0
CAS PubMed Web of Science® Google Scholar
6 Hans, M.;Shimoni, K.;Danino, D.;Siegel, S. J.;Lowman, A. Biomacromolecules 2005, 6, 2708–2717.
10.1021/bm050188k
CAS PubMed Web of Science® Google Scholar
7 Lin, R.;Ng, L. S.;Wang, C.-H. Biomaterials 2005, 26, 4476–4485.
10.1016/j.biomaterials.2004.11.014
CAS PubMed Web of Science® Google Scholar
8 Wang, C.;Wang, C.;Hsiue, G.-H. J Controlled Release 2005, 108, 140–149.
10.1016/j.jconrel.2005.07.017
CAS PubMed Web of Science® Google Scholar
9 Agrawal, S. K.;Sanabria-DeLong, N.;Coburn, J. M.;Tew, G. N.;Bhatia, S. R. J Controlled Release 2006, 112, 64–71.
10.1016/j.jconrel.2005.12.024
CAS PubMed Web of Science® Google Scholar
10 Jiang, X.;Zhang, J.;Zhou, Y.;Xu, J.;Liu, S. J Polym Sci Part A: Polym Chem 2008, 46, 860–871.
10.1002/pola.22430
CAS Web of Science® Google Scholar
11 Wei, H.;Zhang, X.-Z.;Zhou, Y.;Cheng, S.-X.;Zhuo, R.-X. Biomaterials 2006, 27, 2028–2034.
10.1016/j.biomaterials.2005.09.028
CAS PubMed Web of Science® Google Scholar
12 Mendrek, S.;Mendrek, A.;Adler, H.-J.;Walach, W.;Dworak, A.;Kuckling, D. J Polym Sci Part A: Polym Chem 2008, 46, 2488–2499.
10.1002/pola.22581
CAS Web of Science® Google Scholar
13 Zhu, J.-L.;Zhang, X.-Z.;Cheng, H.;Li, Y.-Y.;Cheng, S.-X.;Zhuo R.-X. J Polym Sci Part A: Polym Chem 2007, 45, 5354–5364.
10.1002/pola.22280
CAS Web of Science® Google Scholar
14 Li, G.;Shi, L.;Ma, R.;An, Y.;Huang, N. Angew Chem Int Ed 2006, 45, 4959–4962.
10.1002/anie.200600172
CAS PubMed Web of Science® Google Scholar
15 Ge, Z.;Luo, S.;Shi, L. J Polym Sci Part A: Polym Chem 2006, 44, 1357–1371.
10.1002/pola.21261
CAS Web of Science® Google Scholar
16 Jiang, X.;Xiong, D.;An, Y.;Zheng, P.;Zhang, W.;Shi, L. J Polym Sci Part A: Polym Chem 2007, 45, 2812–2819.
10.1002/pola.22037
CAS Web of Science® Google Scholar
17 Liu, Y.-Y.;Shao, Y.-H.;Lü, J. Biomaterials 2006, 27, 4016–4024.
10.1016/j.biomaterials.2006.02.042
CAS PubMed Web of Science® Google Scholar
18 Nakayama, M.;Chung, J. E.;Miyazaki, T.;Yokoyama, M.;Sakai, K.;Okano, T. React Funct Polym 2007, 67, 1398–1407.
10.1016/j.reactfunctpolym.2007.07.056
CAS Web of Science® Google Scholar
19 Liu, Y.;Fan, X.;Zhao, Y. J Polym Sci Part A: Polym Chem 2005, 43, 3516–3524.
10.1002/pola.20836
CAS Web of Science® Google Scholar
20 Chaw, C. S.;Chooi, K. W.;Liu, X. M.;Tan, C. W.;Wang, L.;Yang, Y. Y. Biomaterials 2004, 25, 4297–4308.
10.1016/j.biomaterials.2003.10.095
CAS PubMed Web of Science® Google Scholar
21 Dai, S.;Ravi, P.;Tam, K. C. Soft Matter 2008, 4, 435–449.
10.1039/b714741d
CAS PubMed Web of Science® Google Scholar
22 Gil, E. S.;Hudson, S. M. Prog Polym Sci 2004, 19, 1173–1222.
10.1016/j.progpolymsci.2004.08.003
CAS Web of Science® Google Scholar
23 Tian, Y.;Bromberg, L.;Lin, S. N.;Hatton, T. A.;Tam, K. C. J Controlled Release 2007, 121, 137–145.
10.1016/j.jconrel.2007.05.010
CAS PubMed Web of Science® Google Scholar
24 Hrubý, M.;Koňák, Č.;Ulbrich, K. J Controlled Release 2005, 103, 137–148.
10.1016/j.jconrel.2004.11.017
CAS PubMed Web of Science® Google Scholar
25 Ma, R.;Wang, B.;Liu, X.;An, Y.;Li, Y.;He, Z.;Shi, L. Langmuir 2007, 23, 7498–7504.
10.1021/la7005925
CAS PubMed Web of Science® Google Scholar
26 Li, Y.;Gong, Y. K.;Nakashima, K. Langmuir 2002, 18, 6727–6729.
10.1021/la025811q
CAS Web of Science® Google Scholar
27 Wu, K.;Shi, L. Q.;Zhang, W. Q.;An, Y. L.;Zhu, X. X.;Zhang, X.;Li, Z. Y. Soft Matter 2005, 6, 455–459.
10.1039/b512610j
CAS Web of Science® Google Scholar
28 Kitaeva, M. V.;Melik-Nubarov, N. S.;Menger, F. M.;Yaroslavov, A. A. Langmuir 2004, 20, 6575–6579.
10.1021/la0497144
CAS PubMed Web of Science® Google Scholar
29 Yang, S. R.;Lee, H. J.;Kim, J. D. J Controlled Release 2006, 114, 60–68.
10.1016/j.jconrel.2006.05.016
CAS PubMed Web of Science® Google Scholar
30 Gillies, E. R.;Frechet, J. M. J. Bioconjug Chem 2005, 16, 361–368.
10.1021/bc049851c
CAS PubMed Web of Science® Google Scholar
31 Li, G.;Shi, L.;An, Y.;Zhang, W.;Ma, R. Polymer 2006, 47, 4581–4587.
10.1016/j.polymer.2006.04.041
CAS Web of Science® Google Scholar
32 Nasongkla, N.;Shuai, X.;Ai, H.;Weinberg, B. D.;Pink, J.;Boothman, D. A. Angew Chem Int Ed 2004, 43, 6323–6327.
10.1002/anie.200460800
CAS PubMed Web of Science® Google Scholar

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Volume46, Issue15

1 August 2008

Pages 5028-5035

Self-assembly of thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) micelles for drug delivery

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Self-assembly of thermo- and pH-responsive poly(acrylic acid)-b-poly(N-isopropylacrylamide) micelles for drug delivery

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