Functional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general-population study
Jan Terock,
Sandra Van der Auwera,
Deborah Janowitz,
Katharina Wittfeld,
Alexander Teumer,
Hans J. Grabe,
Corresponding Author
Jan Terock
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Department of Psychiatry and Psychotherapy, Helios Hanseklinikum Stralsund, Stralsund, Germany
Correspondence
Jan Terock, Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Klinikum Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany.
Email: [email protected]
Search for more papers by this authorSandra Van der Auwera
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorDeborah Janowitz
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorKatharina Wittfeld
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany
Search for more papers by this authorAlexander Teumer
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorHans J. Grabe
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorJan Terock,
Sandra Van der Auwera,
Deborah Janowitz,
Katharina Wittfeld,
Alexander Teumer,
Hans J. Grabe,
Corresponding Author
Jan Terock
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Department of Psychiatry and Psychotherapy, Helios Hanseklinikum Stralsund, Stralsund, Germany
Correspondence
Jan Terock, Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Klinikum Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany.
Email: [email protected]
Search for more papers by this authorSandra Van der Auwera
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorDeborah Janowitz
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorKatharina Wittfeld
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany
Search for more papers by this authorAlexander Teumer
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorHans J. Grabe
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorFunding information
Bundesministerium für Bildung und Forschung (Grants No. 01ZZ9603, 01ZZ0103, 01ZZ0403 and 01ZX1614E).
Abstract
Background
The mineralocorticoid receptor (MR) in the brain has a key role in the regulation of the central stress response and is associated with memory performance. We investigated whether the genetic polymorphisms rs5522 and rs2070951 of NR3C2 showed main and interactive effects with childhood trauma on memory decline.
Methods
Declarative memory was longitudinally assessed in 1,318 participants from the community-dwelling Study of Health in Pomerania using the Verbal Learning and Memory Test (VLMT). In a subsample of 377 participants aged 60 and older, the Mini-Mental Status Examination (MMSE) was additionally applied. Mean follow-up time for the VLMT and MMSE were 6.4 and 10.7 years, respectively.
Results
Homozygous carriers of the G allele of rs2070951 (p < .01) and of the A allele of rs5522 (p < .001) showed higher immediate recall of words as compared to carriers of C allele (rs2070951) or the G allele (rs5522). The CG haplotype was associated with decreased recall (p < .001). Likewise, in the subsample of older patients, the AA genotype of rs5522 was associated with higher MMSE scores (p < .05). CG haplotypes showed significantly reduced MMSE scores in comparison to the reference haplotype (β = −0.60; p < .01).
Conclusions
Our results indicate that the GG genotype of rs2070951 as well as the AA genotype of rs5522 are associated with diminished memory decline.
CONFLICTS OF INTEREST
All authors declare no competing interests.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Supporting Information
| Filename | Description |
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| mgg31345-sup-0001-TblS1-S9-FigS1-S2.docxWord document, 2.5 MB | Tables S1-S9-Figs S1-S2 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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