One-pot Two-step Reaction for Synthesis of Poly-substituted Pyrano[3,2-c]pyridones and Spiro[indoline-3,4′-pyrano[3,2-c]pyridine]-2,5′(6′H)-diones in Water
Zhenhang Xu
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorYijun Du
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorSongxiang Wang
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorZeru Wu
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorYuhao Lou
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorCorresponding Author
Furen Zhang
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
E-mail: [email protected]Search for more papers by this authorZhenhang Xu
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorYijun Du
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorSongxiang Wang
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorZeru Wu
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorYuhao Lou
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
Search for more papers by this authorCorresponding Author
Furen Zhang
School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province, 312000 China
E-mail: [email protected]Search for more papers by this authorAbstract
An efficient four-component approach for the synthesis poly-substituted pyrano[3,2-c]pyridones and spiro[indoline-3,4′-pyrano[3,2-c]pyridine]-2,5′(6′H)-diones in water has been established. During the reaction, the products were readily achieved through one-pot two-step reaction using solid acid as catalyst. The advantages of atom and step economy, the recyclability of heterogeneous solid acid catalyst, easy workup procedure, and the wide scope of substrates make the reaction a powerful tool for assembling pyrano[3,2-c]pyridone skeletons of chemical and medical interest.
Supporting Information
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Data S1. Supporting information |
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