Synthesis and Utility of α,β-Unsaturated Ketone Bearing Naphthalene and Benzofuran Rings in the Synthesis of Some N-heterocycles with Their Antiviral and Antitumor Activity Evaluation

A chalcone bearing naphthalene–benzofuran rings was synthesized. The behavior of this chalcone towards some nitrogen and carbon nucleophiles with formation of pyrazole, isooxazole, thiazole, pyrimidine, pyran, and pyridine rings was studied. Also, pyridine acetohydrazide was synthesized and utilized as a key starting material in the synthesis of 2,4-dioxothiazolidine and 2,4-dioxoquinazolin derivatives. The structures of all the products obtained were illustrated from their analytical and spectral data. Some new compounds were selected and evaluated as antiviral agents against hepatitis A virus. In addition, the antitumor activities of certain selected new compounds were screened, in vitro, against HepG2 and MCF-7 cell lines.