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Therapeutic potential of microRNAs in osteoporosis function by regulating the biology of cells related to bone homeostasis
Wenhua Zhao,
Gengyang Shen,
Hui Ren,
De Liang,
Xiang Yu,
Zhida Zhang,
Jinjing Huang,
Ting Qiu,
Jingjing Tang,
Qi Shang,
Peiyuan Yu,
Zixian Wu,
Xiaobing Jiang,
Wenhua Zhao
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorGengyang Shen
Guangzhou University of Chinese Medicine, Guangzhou, China
Gengyang Shen and Hui Ren have contributed equally as first author.
Search for more papers by this authorHui Ren
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Gengyang Shen and Hui Ren have contributed equally as first author.
Search for more papers by this authorDe Liang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorXiang Yu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorZhida Zhang
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorJinjing Huang
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorTing Qiu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorJingjing Tang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorQi Shang
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorPeiyuan Yu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorZixian Wu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorCorresponding Author
Xiaobing Jiang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Laboratory Affiliated to National Key Discipline of Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
Correspondence Xiaobing Jiang, PhD, MD, Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Email: [email protected]
Search for more papers by this authorWenhua Zhao,
Gengyang Shen,
Hui Ren,
De Liang,
Xiang Yu,
Zhida Zhang,
Jinjing Huang,
Ting Qiu,
Jingjing Tang,
Qi Shang,
Peiyuan Yu,
Zixian Wu,
Xiaobing Jiang,
Wenhua Zhao
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorGengyang Shen
Guangzhou University of Chinese Medicine, Guangzhou, China
Gengyang Shen and Hui Ren have contributed equally as first author.
Search for more papers by this authorHui Ren
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Gengyang Shen and Hui Ren have contributed equally as first author.
Search for more papers by this authorDe Liang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorXiang Yu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorZhida Zhang
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorJinjing Huang
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorTing Qiu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorJingjing Tang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorQi Shang
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorPeiyuan Yu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorZixian Wu
Guangzhou University of Chinese Medicine, Guangzhou, China
Search for more papers by this authorCorresponding Author
Xiaobing Jiang
Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Laboratory Affiliated to National Key Discipline of Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
Correspondence Xiaobing Jiang, PhD, MD, Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Email: [email protected]
Search for more papers by this authorAbstract
MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes through the posttranscriptional regulation of gene expression. Recently, deregulation of the miRNA-mediated mechanism has emerged as an important pathological factor in osteoporosis. However, a detailed molecular mechanism between miRNAs and osteoporosis is still not available. In this review, the roles of miRNAs in the regulation of cells related to bone homeostasis as well as miRNAs that deregulate in human or animal are discussed. Moreover, the miRNAs that act as clusters in the biology of cells in the bone microenvironment and the difference of some important miRNAs for bone homeostasis between bone and other organs are mentioned. Overall, miRNAs that contribute to the pathogenesis of osteoporosis and their therapeutic potential are considered.
CONFLICTS OF INTEREST
The authors declare that there are no conflicts of interest.
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