Synthesis and Cytotoxicity in Vitro of N-Aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine
Corresponding Author
Jiao Ye
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642Search for more papers by this authorMeng-Wu Xiao
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorXuan-Qing Xie
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorShen-Yi Qiu
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorMing-Chong Dai
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorWan Li
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorFang Shen
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorCorresponding Author
Ai-Xi Hu
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642Search for more papers by this authorCorresponding Author
Jiao Ye
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642Search for more papers by this authorMeng-Wu Xiao
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorXuan-Qing Xie
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorShen-Yi Qiu
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorMing-Chong Dai
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorWan Li
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorFang Shen
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
Search for more papers by this authorCorresponding Author
Ai-Xi Hu
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Tel: +86 0731-88822286; Fax: +86 0731-88713642Search for more papers by this authorAbstract
A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines synthesized in a green way. H2O2-NaBr Brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. All of the target compounds were confirmed by 1H NMR and elemental analysis and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound 2i was the most potent compound with the IC50 values of 9 μM against Hela cells and 15 μM against Bel–7402 cells, respectively.
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