Assessment of ALA-induced PpIX production in porcine skin pretreated with microneedles
Corresponding Author
Phamilla Gracielli Sousa Rodrigues
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Corresponding author: e-mail: [email protected], Phone: +5501633739810 (ext. 218)
Search for more papers by this authorPriscila Fernanda Campos de Menezes
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorAlessandra Keiko Lima Fujita
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorAndré Escobar
Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), Jaboticabal-SP, Brazil
Search for more papers by this authorAndrigo Barboza de Nardi
Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), Jaboticabal-SP, Brazil
Search for more papers by this authorCristina Kurachi
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorVanderlei S. Bagnato
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorCorresponding Author
Phamilla Gracielli Sousa Rodrigues
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Corresponding author: e-mail: [email protected], Phone: +5501633739810 (ext. 218)
Search for more papers by this authorPriscila Fernanda Campos de Menezes
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorAlessandra Keiko Lima Fujita
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorAndré Escobar
Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), Jaboticabal-SP, Brazil
Search for more papers by this authorAndrigo Barboza de Nardi
Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), Jaboticabal-SP, Brazil
Search for more papers by this authorCristina Kurachi
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorVanderlei S. Bagnato
Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil
Search for more papers by this authorAbstract
Photodynamic therapy (PDT) is used for skin treatments of premalignant and cancer lesions and recognized as a non-invasive technique that combines tissue photosensitization and subsequent exposure to light to induce cell death. However, it is limited to the treatment of superficial lesions, mainly due to the low cream penetration. Therefore, the improvement of transdermal distribution of aminolevulinic acid (ALA) is needed. In this study, the kinetics and homogeneity of production of ALA-induced PpIX after the skin pre-treatment with microneedles rollers of 0.5, 1.0 and 1.5 mm length were investigated. An improvement in homogeneity and production of PpIX was shown in a porcine model.
Widefield fluorescence imaging three hours after the topical application of ALA-cream in the combined treatment with microeedles rollers.
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