Metal-Organic Framework Nanozyme Enabling Dual-Functional Photo-Induced Charge Transfer and Biomimetic Precipitation for Advanced Organic Photoelectrochemical Transistor Bioanalysis
Ke-Xin Xu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
These authors contribute equally.
Search for more papers by this authorCheng Yuan
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
These authors contribute equally.
Search for more papers by this authorHao Lou
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorFeng-Zao Chen
School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Jiangsu, 318000 China
Search for more papers by this authorLing Zhang
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorCorresponding Author
Guangxu Chen
School of Environment and Energy, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, South China University of Technology, Guangzhou, Guangdong, 510006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
De-Man Han
School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Jiangsu, 318000 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Wei-Wei Zhao
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorKe-Xin Xu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
These authors contribute equally.
Search for more papers by this authorCheng Yuan
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
These authors contribute equally.
Search for more papers by this authorHao Lou
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorFeng-Zao Chen
School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Jiangsu, 318000 China
Search for more papers by this authorLing Zhang
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorCorresponding Author
Guangxu Chen
School of Environment and Energy, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, South China University of Technology, Guangzhou, Guangdong, 510006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
De-Man Han
School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Jiangsu, 318000 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Wei-Wei Zhao
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
We report herein the first observation of MOF nanozyme enabling dual-functional photo-induced charge transfer and biomimetic precipitation for advanced organic photoelectrochemical transistor (OPECT) bioanalysis. Specifically, Fe/Co-MIL-88, serving simultaneously as the semiconductor and nanozyme, was explored as a dual-functional gating module in OPECT. Upon light illumination, it could accelerate the charge transfer of the photogate to produce enhanced photo-induced voltage. Meanwhile, its catalytic property could efficiently produce biomimetic precipitation to block the nanopores in Fe/Co-MIL-88 and thus alter the device characteristics. The generic bioanalytical potential of such a rationale was then demonstrated with an aptasensing assisted by magnetic separation. This work represents the first exploration of biomimetic precipitation from MOF nanozymes for generic OPECT bioanalysis, it is expected to attract more interest in various nanozymes for novel optoelectronic bioanalytics.
Supporting Information
| Filename | Description |
|---|---|
| cjoc202400206_sup_0001_supinfo.pdfPDF document, 956.7 KB |
Appendix S1: Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1 Wang, Q.; Yin, H.; Zhou, Y.; Cao, L.; Yu, Z.; Xu, Y.; Ai, S. Photoelectrochemical Biosensor for 5-Formylcytosine Based on WS2/Bi/Bi2O2CO3 Nanocomposite and Rolling Circle Amplification. Chin. J. Chem. 2022, 40, 247–255.
- 2 Zhu, L.; Zhong, L.; Wang, J.; Tang, Y.; Liu, Z. An Antifouling Photoelectrochemical Ultramicrosensor for Unbiased Single-Cell Analysis. Chin. J. Chem. 2022, 40, 500–506.
- 3 Ruan, Y. F.; Chen, F. Z.; Xu, Y. T.; Zhang, T. Y.; Yu, S. Y.; Zhao, W. W.; Jiang, D.; Chen, H. Y.; Xu, J. J. An Integrated Photoelectrochemical Nanotool for Intracellular Drug Delivery and Evaluation of Treatment Effect. Angew. Chem. Int. Ed. 2021, 60, 25762–25765.
- 4 Wang, H. Y.; Xu, Y. T.; Wang, B.; Yu, S. Y.; Shi, X. M.; Zhao, W. W.; Jiang, D.; Chen, H. Y.; Xu, J. J. A Photoelectrochemical Nanoreactor for Single-Cell Sampling and Near Zero-Background Faradic Detection of Intracellular MicroRNA. Angew. Chem. Int. Ed. 2022, 61, e202212752.
- 5 Yu, S.-Y.; Liu, Y.-L.; Li, Z.; Jiang, D.; Xu, J.-J.; Chen, H.-Y.; Zhao, W.-W., Nature-inspired design of droplet-synthesized polymeric nanoelectrode for photoelectrochemical microRNA sensing within single cells. Sci. Bull. 2024, 69, 159–162.
- 6 Gao, Y.; Tang, J.; Zhou, Q.; Yu, Z.; Wu, D.; Tang, D. Excited-State Intramolecular Proton Transfer-Driven Photon-Gating for Photoelectrochemical Sensing of CO-Releasing Molecule-3. Anal. Chem. 2024, 96, 5014–5021.
- 7 Hu, J.; Lu, M. J.; Chen, F. Z.; Jia, H. M.; Zhou, H.; Li, K.; Zeng, X.; Zhao, W. W.; Lin, P. Multifunctional Hydrogel Hybrid-Gated Organic Photoelectrochemical Transistor for Biosensing. Adv. Funct. Mater. 2022, 32, 2109046.
- 8 Li, C. J.; Hu J.; Gao, G.; Chen, J. H.; Wang, C. S.; Zhou, H.; Chen, G. X.; Qu, P.; Lin, P.; Zhao, W. W. Biomolecules-Incorporated Metal-Organic Frameworks Gated Light-Sensitive Organic Photoelectrochemical Transistor for Biodetection. Adv. Funct. Mater. 2023, 33, 2211277.
- 9 Gao, G.; Chen, J. H.; Jing, M. J.; Hu, J.; Xu, Q.; Wang, C. S.; Zhou, H.; Lin, P.; Chen, G.; Zhao, W. W. Functional Metal-Organic Frameworks for Maximizing Transconductance of Organic Photoelectrochemical Transistor at Zero Gate Bias and Biological Interfacing Application. Adv. Funct. Mater. 2023, 33, 2300580.
- 10 Chen, J. H.; Wang, C. S.; Li, Z.; Hu, J.; Yu, S. Y.; Xu, Y. T.; Lin, P.; Zhao, W. W., Dual Functional Conjugated Acetylenic Polymers: High-Efficacy Modulation for Organic Photoelectrochemical Transistors and Structural Evolution for Bioelectronic Detection. Anal. Chem. 2023, 95, 4243-4250.
- 11 Xu, Y. T.; Li, Z.; Yuan, C.; Wu, J. Q.; Hu, J.; Lin, P.; Zhao, W. W.; Chen, H. Y.; Xu, J. J. Bipolar Modulation of the Ionic Circuit for Generic Organic Photoelectrochemical Transistor Logic and Sensor. Adv. Opt. Mater. 2022, 10, 2102687.
- 12 Yuan, C.; Xu, Y.-T.; Huang, Y.-T.; Zhou, H.; Jiang, X.-W.; Ju, P.; Zhu, Y.-C.; Zhang, L.; Lin, P.; Chen, G.; Zhao, W.-W. Polymer Dot-Gated Accumulation-Type Organic Photoelectrochemical Transistor for Urea Biosensing. ACS Sens. 2023, 8, 1835–1840.
- 13 Corrado, F.; Bruno, U.; Prato, M.; Carella, A.; Criscuolo, V.; Massaro, A.; Pavone, M.; Muñoz-García, A. B.; Forti, S.; Coletti, C.; Bettucci, O.; Santoro, F. Azobenzene-based optoelectronic transistors for neurohybrid building blocks. Nat. Commun. 2023, 14, 6070.
- 14 Druet, V.; Ohayon, D.; Petoukhoff, C. E.; Zhong, Y.; Alshehri, N.; Koklu, A.; Nayak, P. D.; Salvigni, L.; Almulla, L.; Surgailis, J.; Griggs, S.; McCulloch, I.; Laquai, F.; Inal, S. A Single n-type Semiconducting Polymer-based Photo-electrochemical Transistor. Nat. Commun. 2023, 14, 5481.
- 15 Hou, L.; Gao, Y.; Kong, F.-Y.; Wang, Z.-C.; Lin, L.; Han, D.-M.; Chen, F.-Z. Reticular Heterojunction for Organic Photoelectrochemical Transistor Detection of Neuron-Specific Enolase. Small 2024, 2400033.
- 16 Zhao, W. W.; Ma, Z. Y.; Yu, P. P.; Dong, X. Y.; Xu, J. J.; Chen, H. Y. Highly Sensitive Photoelectrochemical Immunoassay with Enhanced Amplification Using Horseradish Peroxidase Induced Biocatalytic Precipitation on a CdS Quantum Dots Multilayer Electrode. Anal. Chem. 2012, 84, 917–923.
- 17 Shen, H.; Qileng, A.; Yang, H.; Liang, H.; Zhu, H.; Liu, Y.; Lei, H.; Liu, W. “Dual-Signal-On” Integrated-Type Biosensor for Portable Detection of miRNA: Cas12a-Induced Photoelectrochemistry and Fluorescence Strategy. Anal. Chem. 2021, 93, 11816–11825.
- 18 Chen, F. Z.; Li, Z.; Liu, X. N.; Zhu, Y. C.; Han, D. M.; Chen, H. Y. Target-Dependent Gating of Nanopores Integrated with H-Cell: Toward A General Platform for Photoelectrochemical Bioanalysis. Anal. Chem. 2021, 93, 5001–5004.
- 19 Zhang, Q.; Yang, H.; Du, C.; Liu, S.; Zhang, X.; Chen, J. Bifunctional Magnetic Fe3O4@Cu2O@TiO2 Nanosphere-Mediated Dual-Mode Assay of PTP1B Activity Based on Photocurrent Polarity Switching and Nanozyme-Engineered Biocatalytic Precipitation Strategies. Anal. Chem. 2022, 94, 13342–13349.
- 20 Zeng, R.; Gong, H.; Li, Y.; Li, Y.; Lin, W.; Tang, D.; Knopp, D. CRISPR-Cas12a-Derived Photoelectrochemical Biosensor for Point- Of-Care Diagnosis of Nucleic Acid. Anal. Chem. 2022, 94, 7442–7448.
- 21 Wang, Y.; Li, L.; Ge, S.; Zhang, L.; Wang, X.; Yu, J. DNAzyme-Mediated Biodeposition Coupling Adjustable Cascade Electric Fields for Photoelectrochemical Telomerase Activity Monitoring. ACS Sens. 2023, 8, 3538–3546.
- 22 Deng, Y.; He, R.; Lu, H.; Guo, Y.; Wang, Q.; Xiao, Y.; Dong, C.; Fan, L. Visible-light driven and efficient photoelectrochemical aptasensor constructed with N-doped carbon quantum dots-decorated TiO2 nanorods for determination of di-2-ethylhexyl phthalate. Chem. Eng. J. 2023, 468, 143583.
- 23 Hu, R.; Ren, X. X.; Song, P.; Wang, A. J.; Mei, L. P.; Feng, J. J. Hollow cage-like PtCu nanozyme-regulated photo-activity of porous CdIn2S4/SnO2 heterojunctions for ultrasensitive PEC sensing of streptomycin. Biosens. Bioelectron. 2023, 236, 115425.
- 24 Wang, C. S.; Zhou, B. Y.; Wang, Y. F.; Yuan, C.; Kou, B. H.; Zhao, W. W.; Xu, J. J. Bifunctional Iron-porphyrin Metal-organic Frameworks for Organic Photoelectrochemical Transistor Gating and Biosensing. Chin. Chem. Lett. 2024, accepted.
- 25 Zhao, X.; Chen, Y.; Niu, R.; Tang, Y.; Chen, Y.; Su, H.; Yang, Z.; Jing, X.; Guan, H.; Gao, R.; Meng, L. NIR Plasmonic Nanozymes: Synergistic Enhancement Mechanism and Multi-Modal Anti-Infection Applications of MXene/MOFs. Adv. Mater. 2024, 36, 2307839.
- 26 Wu, J.; Yu, Y.; Cheng, Y.; Cheng, C.; Zhang, Y.; Jiang, B.; Zhao, X.; Miao, L.; Wei, H. Ligand-Dependent Activity Engineering of Glutathione Peroxidase-Mimicking MIL-47(V) Metal–Organic Framework Nanozyme for Therapy. Angew. Chem. Int. Ed. 2021, 60, 1227–1234.
- 27 Chai, H.; Yu, K.; Zhao, Y.; Zhang, Z.; Wang, S.; Huang, C.; Zhang, X.; Zhang, G. MOF-On-MOF Dual Enzyme-Mimic Nanozyme with Enhanced Cascade Catalysis for Colorimetric/Chemiluminescent Dual-Mode Aptasensing. Anal. Chem. 2023, 95, 10785–10794.
- 28 Kang, Y.; Li, C.; Shi, H.; Zhang, A.; Huang, C.; Zhou, C.; Jia, N. Photothermally Enhanced Dual Enzyme-mimic Activity of Gold-Palladium Hybrid Nanozyme for Cancer Therapy. Chin. J. Chem. 2023, 41, 3189–3196.
- 29 Zuo, L.; King, H.; Hossain, M. A.; Farhana, F.; Kist, M. M.; Stratton, R. L.; Chen, J.; Shen, H. Single-Molecule Spectroscopy Reveals the Plasmon-Assisted Nanozyme Catalysis on AuNR@TiO2. Chem. Biomed. Imaging 2023, 1, 760–766.
- 30 Wang, S.; Ai, Z.; Niu, X.; Yang, W.; Kang, R.; Lin, Z.; Waseem, A.; Jiao, L.; Jiang, H.-L. Linker Engineering of Sandwich-Structured Metal–Organic Framework Composites for Optimized Photocatalytic H2 Production. Adv. Mater. 2023, 35, 2302512.
- 31 Sun, K.; Huang, Y.; Wang, Q.; Zhao, W.; Zheng, X.; Jiang, J.; Jiang, H. L., Manipulating the Spin State of Co Sites in Metal–Organic Frameworks for Boosting CO2 Photoreduction. J. Am. Chem. Soc. 2024, DOI: https://doi.org/10.1021/jacs.3c11446.
- 32 Cao, J.; Tang, G.; Yan, F. Applications of Emerging Metal and Covalent Organic Frameworks in Perovskite Photovoltaics: Materials and Devices. Adv. Energy Mater. 2024, 14, 2304027.
