Concise Report
Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite
Xiang-Long Chen,
Chun-Yan Wu,
Dong-Sheng Yang,
Bo-Cheng Tang,
Huai-Yu Wang,
Zhi-Cheng Yu,
Anling Li,
Yan-Dong Wu,
An-Xin Wu,
Xiang-Long Chen
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorChun-Yan Wu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorDong-Sheng Yang
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorBo-Cheng Tang
State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China
Search for more papers by this authorHuai-Yu Wang
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorZhi-Cheng Yu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorCorresponding Author
Anling Li
Department of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430062 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yan-Dong Wu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
An-Xin Wu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorXiang-Long Chen,
Chun-Yan Wu,
Dong-Sheng Yang,
Bo-Cheng Tang,
Huai-Yu Wang,
Zhi-Cheng Yu,
Anling Li,
Yan-Dong Wu,
An-Xin Wu,
Xiang-Long Chen
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorChun-Yan Wu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorDong-Sheng Yang
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorBo-Cheng Tang
State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR, China
Search for more papers by this authorHuai-Yu Wang
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorZhi-Cheng Yu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
Search for more papers by this authorCorresponding Author
Anling Li
Department of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430062 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yan-Dong Wu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
An-Xin Wu
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years, however, the use of green and readily available reducing salt to mediate these reactions remains to be explored. In this work, a concise construction of gem-difluoroalkenes, which requires neither a catalyst nor a metal reducing agent, was established. Rongalite, a safe and inexpensive industrial product, was employed as both a radical initiator and reductant. This procedure was compatible with both linear and cyclic diaryliodonium salts, enabling a wide variety of substrates (>70 examples). The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.
Supporting Information
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Appendix S1: Supporting Information |
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