Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes†
Bin Lu
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
These authors contributed equally to this work.
Search for more papers by this authorFeng-Shuo Bao
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
These authors contributed equally to this work.
Search for more papers by this authorZi-Wei He
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
Search for more papers by this authorWen-Jing Xiao
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
Wuhan Institute of Photochemistry and Technology, 7 North Bingang Road, Wuhan, Hubei, 430083 China
Search for more papers by this authorCorresponding Author
Jia-Rong Chen
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
Wuhan Institute of Photochemistry and Technology, 7 North Bingang Road, Wuhan, Hubei, 430083 China
Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi, 341000 China
*E-mail: [email protected]Search for more papers by this authorBin Lu
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
These authors contributed equally to this work.
Search for more papers by this authorFeng-Shuo Bao
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
These authors contributed equally to this work.
Search for more papers by this authorZi-Wei He
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
Search for more papers by this authorWen-Jing Xiao
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
Wuhan Institute of Photochemistry and Technology, 7 North Bingang Road, Wuhan, Hubei, 430083 China
Search for more papers by this authorCorresponding Author
Jia-Rong Chen
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079 China
Wuhan Institute of Photochemistry and Technology, 7 North Bingang Road, Wuhan, Hubei, 430083 China
Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi, 341000 China
*E-mail: [email protected]Search for more papers by this authorDedicated to the Special Issue of C1 Chemistry.
Comprehensive Summary
Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl compounds. Given the significance of fluorine-containing groups, this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal catalysis. Herein, we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst. A wide range of alkenes and amines were well tolerated, providing the valuable β-perfluoroalkylated amides with generally good yields and high chemoselectivity.
Supporting Information
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Appendix S1: Supporting Information |
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