Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell†
Ting Liu
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
These authors contributed equally to this work.
Search for more papers by this authorZhaojiang Shi
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
These authors contributed equally to this work.
Search for more papers by this authorYaofeng Yuan
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
Search for more papers by this authorCorresponding Author
Yuqi Lin
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Ke-Yin Ye
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
E-mail: [email protected]; [email protected]Search for more papers by this authorTing Liu
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
These authors contributed equally to this work.
Search for more papers by this authorZhaojiang Shi
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
These authors contributed equally to this work.
Search for more papers by this authorYaofeng Yuan
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
Search for more papers by this authorCorresponding Author
Yuqi Lin
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Ke-Yin Ye
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108 China
E-mail: [email protected]; [email protected]Search for more papers by this authorDedicated to the Special Issue of Emerging Investigators in 2024.
Comprehensive Summary
The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and agrochemicals. Herein, we disclose an electrochemical dearomative spirocyclization of N-acyl sulfonamides in a continuous-flow cell. The reaction is simple and efficient without external catalysts or supporting electrolytes and could be applied in a decagram-scale synthesis.
Supporting Information
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Appendix S1: Supporting Information |
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