Volume 42, Issue 1 pp. 87-103
Critical Review

Bioactive Hydrogels with Pro-coagulation Effect for Hemostasis

Quanshi Guo

Quanshi Guo

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310058 China

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009 China

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Yihang Ding

Yihang Ding

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310058 China

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Lisha Yu

Corresponding Author

Lisha Yu

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009 China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, Zhejiang, 310009 China

E-mail: [email protected] (Z.M.); [email protected] (Z.T.); [email protected] (L.Y.)Search for more papers by this author
Zongrui Tong

Corresponding Author

Zongrui Tong

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009 China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, Zhejiang, 310009 China

E-mail: [email protected] (Z.M.); [email protected] (Z.T.); [email protected] (L.Y.)Search for more papers by this author
Zhengwei Mao

Corresponding Author

Zhengwei Mao

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310058 China

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009 China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, Zhejiang, 310009 China

E-mail: [email protected] (Z.M.); [email protected] (Z.T.); [email protected] (L.Y.)Search for more papers by this author
First published: 23 August 2023
Citations: 1

Dedicated to the Special Issue of Hydrogels.

Comprehensive Summary

Hemostatic hydrogels are widely applied for wound management of damaged tissues, traumatic wounds, and surgical incisions. Some hydrogels composed of bioactive components, including fibrin and thrombin, showed great promise in the clinic due to their good pro-coagulation effect. With the expanding knowledge of cascade reaction of blood coagulation and emerging bioactive substances, massive bioactive hydrogels consisting of peptides, hemocoagulase, polyphosphate (polyP), etc., have been developed as effective hemostatic materials. Based on the coagulation process and mechanism, we summarize the role of reported bioactive hydrogels in hemostasis in this review. We conclude the key points in the coagulation process, including activation of coagulation factors, fibrinogen polymerization, etc., then discuss how to design bioactive hydrogels to accelerate coagulation targeted to these points. Finally, we conclude the progress and propose a perspective of bioactive hydrogels with a pro-coagulation effect for hemostasis.image

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