Recent Advances
Unlocking G-Quadruplexes as Targets and Tools against COVID-19
Geng Qin,
Chuanqi Zhao,
Jie Yang,
Zhao Wang,
Jinsong Ren,
Xiaogang Qu,
Geng Qin
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorChuanqi Zhao
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorJie Yang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorZhao Wang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorJinsong Ren
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorCorresponding Author
Xiaogang Qu
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
E-mail: [email protected]Search for more papers by this authorGeng Qin,
Chuanqi Zhao,
Jie Yang,
Zhao Wang,
Jinsong Ren,
Xiaogang Qu,
Geng Qin
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorChuanqi Zhao
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorJie Yang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorZhao Wang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorJinsong Ren
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
Search for more papers by this authorCorresponding Author
Xiaogang Qu
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Science, Changchun, Jilin, 130022 China
University of Science and Technology of China, Hefei, Anhui, 230026 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
The applicability of G-quadruplexes (G4s) as antiviral targets, therapeutic agents and diagnostic tools for coronavirus disease 2019 (COVID-19) is currently being evaluated, which has drawn the extensive attention of the scientific community. During the COVID-19 pandemic, research in this field is rapidly accumulating. In this review, we summarize the latest achievements and breakthroughs in the use of G4s as antiviral targets, therapeutic agents and diagnostic tools for COVID-19, particularly using G4 ligands. Finally, strength and weakness regarding G4s in anti-SARS-CoV-2 field are highlighted for prospective future projects.
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