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New Amines and Activation Modes in Asymmetric Aminocatalysis
Zhi-Chao Chen,
Wei Du,
Ying-Chun Chen,
Zhi-Chao Chen
Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorWei Du
Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Ying-Chun Chen
Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
College of Pharmacy, Third Military Medical University, Shapingba, Chongqing, 400038 China
E-mail: [email protected]Search for more papers by this authorZhi-Chao Chen,
Wei Du,
Ying-Chun Chen,
Zhi-Chao Chen
Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorWei Du
Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Ying-Chun Chen
Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041 China
College of Pharmacy, Third Military Medical University, Shapingba, Chongqing, 400038 China
E-mail: [email protected]Search for more papers by this authorAbstract
Asymmetric aminocatalysis has become one of the most powerful strategies for the transformations of carbonyl substances over the past two decades. Here, we describe the research from our laboratory that significantly expands the horizon of aminocatalysis. It includes the development and application of cinchona-based primary amines, fruitful reactions based on HOMO-raising strategy, and the disclosure of amine/thiol double activation catalysis.
What is the most favorite and original chemistry developed in your research group?
Cinchona-based primary amine catalysts and trienamine activation mode.
How do you get into this specific field? Could you please share some experiences with our readers?
I got to know asymmetric catalysis when I began to pursue my PhD study, and realized the importance and beauty of chiral substances. My key experiences in research are: try something different, and be sensitive to the difference.
How do you supervise your students?
Always keep honest, and try to understand what you are doing.
What are your hobbies?
Gardening and badminton.
How do you keep balance between research and family?
Keep communicating with family members.
Who influences you mostly in your life?
My PhD director Prof. Yao-Zhong Jiang.
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