Copper(I)-Catalyzed Intramolecular Direct C-Arylation of Azoles with Aryl Bromides
Yuan Huang
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorWei Chen
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorDan Zhao
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorChen Chen
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorHuiqing Yin
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorLikang Zheng
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorMing Jin
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorCorresponding Author
Shiqing Han
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Key Laboratory of Synthetic Chemistry of Natural Products, Shanghai Institute of Organic Chemistry, CAS, Shanghai 200032, China
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China, Tel.: 0086-025-58139970; Fax: 0086-025-58139369Search for more papers by this authorYuan Huang
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorWei Chen
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorDan Zhao
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorChen Chen
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorHuiqing Yin
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorLikang Zheng
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorMing Jin
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Search for more papers by this authorCorresponding Author
Shiqing Han
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China
Key Laboratory of Synthetic Chemistry of Natural Products, Shanghai Institute of Organic Chemistry, CAS, Shanghai 200032, China
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu 211816, China, Tel.: 0086-025-58139970; Fax: 0086-025-58139369Search for more papers by this authorAbstract
A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper(I)-catalyzed intramolecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanthroline as ligand, and K3PO4 as base, the reactions of 1-(2-bromobenzyl)-1H-imidazoles in DMF/o-xylene (1:1, V:V) at 145°C afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecular C-arylation.
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