Copper-Mediated Trifluoromethylation of Terminal Alkynes by S-(Trifluoromethyl)diarylsulfonium Salt
Xiaoping Wang
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, China
Search for more papers by this authorJinhong Lin
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorChengpan Zhang
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorCorresponding Author
Jichang Xiao
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, Tel.: 0086-021-54925340; Fax: 0086-021-64166128Search for more papers by this authorXing Zheng
Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, China
Search for more papers by this authorXiaoping Wang
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, China
Search for more papers by this authorJinhong Lin
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorChengpan Zhang
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorCorresponding Author
Jichang Xiao
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, Tel.: 0086-021-54925340; Fax: 0086-021-64166128Search for more papers by this authorXing Zheng
Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, China
Search for more papers by this authorAbstract
The copper-mediated trifluoromethylation of terminal alkynes with S-(trifluoromethyl)diarylsulfonium salt has been carefully investigated. The reactions proceeded smoothly to afford trifluoromethylated acetylenes in moderate to good yields. This approach is a convenient method to synthesize a variety of functional trifluoromethylated acetylenes.
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