Artemisinin, ein ungewöhnliches tetracyclisches, endoperoxidisches Sesquiterpen ist ein wegen der überragenden Wirkung gegen den Malariaparasiten außergewöhnlich intensiv erforschter, bioaktiver Naturstoff. Seine chinesische Entdeckerin Tu Youyou erhielt dafür 2015 den Nobelpreis für Medizin. Als Malariawirkstoff ist sein Potential aber nicht ausgeschöpft. Wir setzen die beiden ChiuZ-Beiträge von 2014 über Artemisinin fort und beschreiben die Isolierung von Artemisinin aus Blättern des Einjährigen Beifußes. Wir präsentieren und interpretieren den kompletten Satz analytischer Spektren zur Strukturzuordnung. Hintergrundinformationen ergänzen das Bild.

Abstract

Artemisinin, an unusual tetracyclic, endoperoxidic sesquiterpene is a highly bioactive natural product. Due to its superior activity against the malaria parasite it is under investigation to an extraordinary extent. The Chinese scientist Tu Youyou who discovered the compound received the Nobel Prize for medicine 2015. However, treating malaria is not all of its potential. This paper is following up two recent articles on artemisinin in this Journal from 2014. We describe here the isolation of pure crystalline artemisinin from dried sweet wormwood leaves and present its complete set of spectra together with interpretations. Background information complements the matter.

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Volume50, Issue5

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Naturstoffe isolieren und charakterisieren

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Ein Wirkstoff gegen Malaria aus der Natur: Artemisinin

Nobelpreisgekrönt: Qinghaosu,

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Ein Wirkstoff gegen Malaria aus der Natur: Artemisinin

Nobelpreisgekrönt: Qinghaosu,

Correction(s) for this article

Korrektur zu Chiuz 5/2016, S. 329

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