Review
Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography
Kyung-Min Kim,
Ju Weon Lee,
Sunhee Kim,
Francisco Vitor Santos da Silva,
Andreas Seidel-Morgenstern,
Chang-Ha Lee,
Kyung-Min Kim
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
KEPCO Research Institute, Creative Future Laboratory, 105 Munji-ro, Yuseong-gu, 34056 Daejeon, Korea
These authors contributed equally.
Search for more papers by this authorJu Weon Lee
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
These authors contributed equally.
Search for more papers by this authorSunhee Kim
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
Search for more papers by this authorFrancisco Vitor Santos da Silva
Max Planck Institute for Dynamics of Complex Technical Systems, Physical and Chemical Foundations of Process Engineering, Sandtorstrasse 1, 39106 Magdeburg, Germany
Search for more papers by this authorCorresponding Author
Andreas Seidel-Morgenstern
Max Planck Institute for Dynamics of Complex Technical Systems, Physical and Chemical Foundations of Process Engineering, Sandtorstrasse 1, 39106 Magdeburg, Germany
Otto-von-Guericke University, Chair of Chemical Process Engineering, Universitätsplatz 2, 39106 Magdeburg, Germany
Correspondence: Andreas Seidel-Morgenstern ([email protected]), Otto-von-Guericke University, Chair of Chemical Process Engineering, Universitätsplatz 2, 39106 Magdeburg, Germany. Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.Search for more papers by this authorCorresponding Author
Chang-Ha Lee
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
Correspondence: Andreas Seidel-Morgenstern ([email protected]), Otto-von-Guericke University, Chair of Chemical Process Engineering, Universitätsplatz 2, 39106 Magdeburg, Germany. Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.Search for more papers by this authorKyung-Min Kim,
Ju Weon Lee,
Sunhee Kim,
Francisco Vitor Santos da Silva,
Andreas Seidel-Morgenstern,
Chang-Ha Lee,
Kyung-Min Kim
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
KEPCO Research Institute, Creative Future Laboratory, 105 Munji-ro, Yuseong-gu, 34056 Daejeon, Korea
These authors contributed equally.
Search for more papers by this authorJu Weon Lee
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
These authors contributed equally.
Search for more papers by this authorSunhee Kim
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
Search for more papers by this authorFrancisco Vitor Santos da Silva
Max Planck Institute for Dynamics of Complex Technical Systems, Physical and Chemical Foundations of Process Engineering, Sandtorstrasse 1, 39106 Magdeburg, Germany
Search for more papers by this authorCorresponding Author
Andreas Seidel-Morgenstern
Max Planck Institute for Dynamics of Complex Technical Systems, Physical and Chemical Foundations of Process Engineering, Sandtorstrasse 1, 39106 Magdeburg, Germany
Otto-von-Guericke University, Chair of Chemical Process Engineering, Universitätsplatz 2, 39106 Magdeburg, Germany
Correspondence: Andreas Seidel-Morgenstern ([email protected]), Otto-von-Guericke University, Chair of Chemical Process Engineering, Universitätsplatz 2, 39106 Magdeburg, Germany. Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.Search for more papers by this authorCorresponding Author
Chang-Ha Lee
Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, 03722 Seoul, Korea
Correspondence: Andreas Seidel-Morgenstern ([email protected]), Otto-von-Guericke University, Chair of Chemical Process Engineering, Universitätsplatz 2, 39106 Magdeburg, Germany. Yonsei University, Department of Chemical and Biomolecular Engineering, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.Search for more papers by this authorAbstract
Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high-purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.
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