Volumetric Mass Transfer Coefficient in Fermenters: Scale-up Study in Viscous Liquids
Corresponding Author
Radim Petříček
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Correspondence: Radim Petříček ([email protected]), University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic.Search for more papers by this authorLibor Labík
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorTomáš Moucha
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorFrantišek Jonáš Rejl
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorLukáš Valenz
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorJan Haidl
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorCorresponding Author
Radim Petříček
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Correspondence: Radim Petříček ([email protected]), University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic.Search for more papers by this authorLibor Labík
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorTomáš Moucha
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorFrantišek Jonáš Rejl
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorLukáš Valenz
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorJan Haidl
University of Chemistry and Technology, Chemical Engineering Department, Technická 5, 166 28 Praha 6, Czech Republic
Search for more papers by this authorAbstract
In the design of mechanically agitated fermenters, the volumetric mass transfer coefficient kLa often becomes the key parameter. In case of viscous liquids, kLa prediction based on literature correlations suffers from a wide distribution. The aim is to provide reliable kLa correlations based on a large experimental data set obtained using the dynamic pressure method, the physical correctness of which was verified earlier. Multiple-impeller fermenters of two scales were used. The impeller tip speed, rather than the power input, revealed to be the proper term for prediction of kLa. When the impeller power number is used, kLa values for various impeller types can be predicted by a common correlation which, based on a wide range of operational conditions, can be applied in the design.
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