Production of High-Tensile-Strength Paracetamol Tablets Using the Freeze-Casting Process

A fast-dissolving solid dosage form (tablet), containing in this case paracetamol as an active pharmaceutical ingredient and modified starch as an additive, was successfully produced by means of the freeze-casting process. The structure and two key properties, namely, disintegration time and tensile strength, of freeze-casted tablets were investigated. The produced tablets exhibit a threefold faster disintegration time with equal tensile strength in comparison to the commercial compressed tablets. Sugar as a binder, however, can just improve the disintegration rate but not enhance the tensile strength due to different mechanisms working.