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Crystallization and Resolution of cis-Permethric Acid with Carbon Dioxide Antisolvent

György Bánsághi

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.

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László Lőrincz,

László Lőrincz

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.

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Imre Miklós Szilágyi,

Imre Miklós Szilágyi

Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Budapest, Hungary.

MTA-BME Technical Analytical Chemistry Research Group, Budapest, Hungary.

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János Madarász,

János Madarász

Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Budapest, Hungary.

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Edit Székely,

Corresponding Author

Edit Székely

[email protected]

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.===Search for more papers by this author

György Bánsághi,

György Bánsághi

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.

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László Lőrincz,

László Lőrincz

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.

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Imre Miklós Szilágyi,

Imre Miklós Szilágyi

Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Budapest, Hungary.

MTA-BME Technical Analytical Chemistry Research Group, Budapest, Hungary.

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János Madarász,

János Madarász

Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Budapest, Hungary.

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Edit Székely,

Corresponding Author

Edit Székely

[email protected]

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.

Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, Hungary.===Search for more papers by this author

First published: 09 July 2014

https://doi.org/10.1002/ceat.201300718

Citations: 12

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Abstract

Crystallization and resolution of cis-permethric acid (cPA) with (1R)-1-phenylethanamine (PhEA) as a resolving agent was investigated by means of gas antisolvent (GAS) and supercritical antisolvent (SAS) methods. A significant pressure effect on both the yields and diastereomeric excesses of the crystallized cPA-PhEA salts was observed in a defined pressure range. The pressure effect was found to be related to the structure and dissociation of the salts. Both methods yielded diastereomeric salts with excellent diastereoselectivity, compared to data reported in literature, and a fibrous structure of uniform fiber diameter.

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Volume37, Issue8

Special Issue:Industrial Crystallization

August, 2014

Pages 1417-1421

Crystallization and Resolution of cis-Permethric Acid with Carbon Dioxide Antisolvent

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Crystallization and Resolution of cis-Permethric Acid with Carbon Dioxide Antisolvent

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