Volume 21, Issue 6 e202400519

Research Article

Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis

Jiao Liu,

Jiao Liu

School of Medicine, Shanghai University, Shanghai, 200444 China

These authors contributed equally to this work.

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Zi-Yi Liu,

Zi-Yi Liu

School of Pharmaceutical Science, Nanchang University, Nanchang, 330006 China

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China

These authors contributed equally to this work.

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Yan Fu,

Yan Fu

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China

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Yu-Cheng Gu,

Yu-Cheng Gu

Jealott's Hill International Research Centre, Syngenta, Bracknell, Berkshire, RG42 6EY United Kingdom

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Song-Wei Li,

Corresponding Author

Song-Wei Li

[email protected]

School of Medicine, Shanghai University, Shanghai, 200444 China

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Hai-Yan Zhang,

Corresponding Author

Hai-Yan Zhang

[email protected]

School of Pharmaceutical Science, Nanchang University, Nanchang, 330006 China

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China

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Yue-Wei Guo,

Corresponding Author

Yue-Wei Guo

[email protected]

orcid.org/0000-0003-0413-2070

School of Medicine, Shanghai University, Shanghai, 200444 China

Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117 China

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Jiao Liu,

Jiao Liu

School of Medicine, Shanghai University, Shanghai, 200444 China

These authors contributed equally to this work.

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Zi-Yi Liu,

Zi-Yi Liu

School of Pharmaceutical Science, Nanchang University, Nanchang, 330006 China

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China

These authors contributed equally to this work.

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Yan Fu,

Yan Fu

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China

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Yu-Cheng Gu,

Yu-Cheng Gu

Jealott's Hill International Research Centre, Syngenta, Bracknell, Berkshire, RG42 6EY United Kingdom

Search for more papers by this author

Song-Wei Li,

Corresponding Author

Song-Wei Li

[email protected]

School of Medicine, Shanghai University, Shanghai, 200444 China

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Hai-Yan Zhang,

Corresponding Author

Hai-Yan Zhang

[email protected]

School of Pharmaceutical Science, Nanchang University, Nanchang, 330006 China

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China

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Yue-Wei Guo,

Corresponding Author

Yue-Wei Guo

[email protected]

orcid.org/0000-0003-0413-2070

School of Medicine, Shanghai University, Shanghai, 200444 China

Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117 China

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First published: 04 April 2024

https://doi.org/10.1002/cbdv.202400519

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Abstract

One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells.

Graphical Abstract

Conflict of interests

The authors declare no conflict of interest.

Open Research

Data Availability Statement

The data that support the findings of this study are available in the supplementary material of this article.

Supporting Information

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Volume21, Issue6

June 2024

e202400519

Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis

Abstract

Graphical Abstract

Conflict of interests

Open Research

Data Availability Statement

Supporting Information

References

References

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Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis

Abstract

Graphical Abstract

Conflict of interests

Open Research

Data Availability Statement

Supporting Information

References

References

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