Active Constituents with Tyrosinase Inhibitory Activities from Waste Tobacco Leaves
Mei Zhang
College of Pharmacy, Guizhou University, South section of Huaxi Road 2078, Guiyang, 550025 P.R. China
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorJia-Yu Sun
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorHong-Mao Qiu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorPeng Zhang
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorLu-Lu Deng
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorJiang Li
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorXiao-Jiang Hao
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Kunming Institute of Botany, Chinese Academy of Sciences (CAS), 132 Lanhei Road, Kunming, 650201 P. R. China
Search for more papers by this authorCorresponding Author
Xian-Kun Su
Guizhou Academy of Tobacco Science, No.29 Longtanba Road, Guiyang, 550081 P. R. China
Search for more papers by this authorCorresponding Author
Shu-Zhen Mu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorMei Zhang
College of Pharmacy, Guizhou University, South section of Huaxi Road 2078, Guiyang, 550025 P.R. China
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorJia-Yu Sun
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorHong-Mao Qiu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorPeng Zhang
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorLu-Lu Deng
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorJiang Li
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorXiao-Jiang Hao
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Kunming Institute of Botany, Chinese Academy of Sciences (CAS), 132 Lanhei Road, Kunming, 650201 P. R. China
Search for more papers by this authorCorresponding Author
Xian-Kun Su
Guizhou Academy of Tobacco Science, No.29 Longtanba Road, Guiyang, 550081 P. R. China
Search for more papers by this authorCorresponding Author
Shu-Zhen Mu
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang, 550014 P. R. China
Search for more papers by this authorAbstract
One novel compound, (R)-3, 6-diethoxy-4-hydroxycyclohex-3-en-1-one (1) and thirteen known compounds were isolated from the waste tobacco leaves. The structures of two compounds (1–2) were confirmed and attributed firstly by the extensive spectroscopic data, including 1D/2D NMR, IR, HR-ESI-MS, CD, and ECD spectra. Notably, seven compounds (2, 3, 9, 10, 11, 12, and 13) exhibited better tyrosinase inhibitory activity than the positive control kojic acid. The binding modes of these compounds revealed that their structure formed strong hydrogen bonds and van der Waals forces with the active sites of tyrosinase. These results indicated that waste tobacco leaves are good resources for developing tyrosinase inhibitors.
Graphical Abstract
Conflict of interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.{, #1}
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