Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights
Naoual El Menyiy
Laboratory of Pharmacology, National Agency of Medicinal and Aromatic Plants, Taounate, 34025 Morocco
Search for more papers by this authorYoussef Elouafy
Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat, BP 1014 Morocco
Search for more papers by this authorRania Moubachir
Bioactives and Environmental Health Laboratory, Faculty of Sciences, Moulay Ismail University, 11201 Meknes, Marocco
Search for more papers by this authorRhizlan Abdnim
Laboratoire de bioressources, biotechnologie, ethnopharmacologie et santé, Département de biologie, Faculté des sciences, Université Mohamed premier, Boulevard Mohamed VI; BP:717, 60000 Oujda, Marocco
Search for more papers by this authorTaoufiq Benali
Environment and Health Team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Marrakesh-Safi, 46030 Morocco
Search for more papers by this authorDouae Taha
Molecular Modeling, Materials, Nanomaterials, Water and Environment Laboratory, CERNE2D, Department of Chemistry, Faculty of Sciences, Mohammed V University, Rabat, Rabat, 10106 Morocco
Search for more papers by this authorCorresponding Author
Asaad Khalid
Substance Abuse and Toxicology Research Unit, Health Research Cener, Jazan University, P.O. Box: 114, Jazan, 11111 Saudi Arabia
Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, P. O. Box 2404, 11111 Khartoum, Sudan
Search for more papers by this authorAshraf N. Abdalla
Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, 21955 Saudi Arabia
Search for more papers by this authorSiddiqa M. A. Hamza
Department of Pathology, College of Medicine, Umm Alqura University, 24832 Alqunfudah, Saudi Arabia
Search for more papers by this authorSalma Elhadi Ibrahim
Department of Physiology, College of Medicine, Umm Alqura University, 24832 Alqunfudah, Saudi Arabia
Search for more papers by this authorMohamed El-Shazly
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt
Search for more papers by this authorCorresponding Author
Gokhan Zengin
Department of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey
Search for more papers by this authorCorresponding Author
Abdelhakim Bouyahya
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, 10106 Morocco
Search for more papers by this authorNaoual El Menyiy
Laboratory of Pharmacology, National Agency of Medicinal and Aromatic Plants, Taounate, 34025 Morocco
Search for more papers by this authorYoussef Elouafy
Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat, BP 1014 Morocco
Search for more papers by this authorRania Moubachir
Bioactives and Environmental Health Laboratory, Faculty of Sciences, Moulay Ismail University, 11201 Meknes, Marocco
Search for more papers by this authorRhizlan Abdnim
Laboratoire de bioressources, biotechnologie, ethnopharmacologie et santé, Département de biologie, Faculté des sciences, Université Mohamed premier, Boulevard Mohamed VI; BP:717, 60000 Oujda, Marocco
Search for more papers by this authorTaoufiq Benali
Environment and Health Team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Marrakesh-Safi, 46030 Morocco
Search for more papers by this authorDouae Taha
Molecular Modeling, Materials, Nanomaterials, Water and Environment Laboratory, CERNE2D, Department of Chemistry, Faculty of Sciences, Mohammed V University, Rabat, Rabat, 10106 Morocco
Search for more papers by this authorCorresponding Author
Asaad Khalid
Substance Abuse and Toxicology Research Unit, Health Research Cener, Jazan University, P.O. Box: 114, Jazan, 11111 Saudi Arabia
Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, P. O. Box 2404, 11111 Khartoum, Sudan
Search for more papers by this authorAshraf N. Abdalla
Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, 21955 Saudi Arabia
Search for more papers by this authorSiddiqa M. A. Hamza
Department of Pathology, College of Medicine, Umm Alqura University, 24832 Alqunfudah, Saudi Arabia
Search for more papers by this authorSalma Elhadi Ibrahim
Department of Physiology, College of Medicine, Umm Alqura University, 24832 Alqunfudah, Saudi Arabia
Search for more papers by this authorMohamed El-Shazly
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt
Search for more papers by this authorCorresponding Author
Gokhan Zengin
Department of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey
Search for more papers by this authorCorresponding Author
Abdelhakim Bouyahya
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, 10106 Morocco
Search for more papers by this authorAbstract
Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic, and anti-tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
Graphical Abstract
Conflict of interests
The authors declare no conflict of interest.
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