Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase
Vagif Farzaliyev
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Baku State University, Z. Khalilov Str. 23, AZ-1148 Baku, Azerbaijan
Search for more papers by this authorAdem Ertürk
Ataturk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Türkiye
Search for more papers by this authorMalahat Abbasova
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Search for more papers by this authorOruj Nabiyev
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Search for more papers by this authorCorresponding Author
Dr. Yeliz Demir
- [email protected]
- [email protected]
- +905363759547 | Fax: +904782117552
Ardahan University, Nihat Delibalta Göle Vocational High School, Department of Pharmacy Services, 75700 Ardahan, Türkiye
Search for more papers by this authorHatice Kızıltaş
Van Yüzüncü Yıl University, Van Vocational School of Health Services, 65080 Van, Türkiye
Contribution: Formal analysis (equal), Investigation (equal)
Search for more papers by this authorAfsun Sujayev
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Search for more papers by this authorİlhami Gülçin
Ataturk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Türkiye
Search for more papers by this authorVagif Farzaliyev
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Baku State University, Z. Khalilov Str. 23, AZ-1148 Baku, Azerbaijan
Search for more papers by this authorAdem Ertürk
Ataturk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Türkiye
Search for more papers by this authorMalahat Abbasova
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Search for more papers by this authorOruj Nabiyev
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Search for more papers by this authorCorresponding Author
Dr. Yeliz Demir
- [email protected]
- [email protected]
- +905363759547 | Fax: +904782117552
Ardahan University, Nihat Delibalta Göle Vocational High School, Department of Pharmacy Services, 75700 Ardahan, Türkiye
Search for more papers by this authorHatice Kızıltaş
Van Yüzüncü Yıl University, Van Vocational School of Health Services, 65080 Van, Türkiye
Contribution: Formal analysis (equal), Investigation (equal)
Search for more papers by this authorAfsun Sujayev
Institute of Chemistry of Additives, Ministry of Science and Education of the Republic of Azerbaijan, 1029 Baku, Azerbaijan
Search for more papers by this authorİlhami Gülçin
Ataturk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Türkiye
Search for more papers by this authorAbstract
1,3-Diheterocycloalkanes derivatives are important starting materials in fine organic synthesis. These compounds can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. The paper is focused on synthesis and study of alkoxymethyl derivatives of diheterocycloalkanes (M1–M15) and inhibition effect on carbonic anhydrase and acetylcholinesterase. The structures of compounds were confirmed by 1H and 13C NMR spectroscopy. Also, in this study alkoxymethyl derivatives of diheterocycloalkanes were assessed for their influence on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoenzymes (hCA I and hCA II). The results demonstrated that all these compounds exhibited potent inhibitory effects on all the target enzymes, surpassing the standard inhibitors, as evidenced by their IC50 and Ki values. The Ki values for the compounds concerning AChE, hCA I, and hCA II enzymes were in the ranges of 1.02±0.17–8.38±1.02, 15.30±3.15–58.14±5.17 and 24.05±3.70–312.94±27.24 nM, respectively.
Graphical Abstract
Conflict of interests
The authors declare no conflict of interest.
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