The antimalarial activity of indole alkaloids and hybrids
Jue-Ying Li
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorCorresponding Author
Xiao-Feng Sun
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Correspondence Xiao-Feng Sun, Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 430074 Wuhan, China.
Email: [email protected]
Search for more papers by this authorJing-Jing Li
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorFen Yu
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorYi Zhang
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorXiu-Juan Huang
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorFeng-Xia Jiang
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorJue-Ying Li
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorCorresponding Author
Xiao-Feng Sun
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Correspondence Xiao-Feng Sun, Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 430074 Wuhan, China.
Email: [email protected]
Search for more papers by this authorJing-Jing Li
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorFen Yu
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorYi Zhang
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorXiu-Juan Huang
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorFeng-Xia Jiang
Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorAbstract
Malaria, caused by the genus Plasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug-resistant parasite strains. Indole derivatives, which possess broad-spectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug-sensitive and drug-resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents. This review outlines the advances in indole alkaloids and hybrids with antimalarial potential in the recent decade.
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