Effect of different initiators on temperature-sensitive monolithic columns and application in online enrichment of β-sitosterol
Bin Guo
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorHuimin Wang
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorDanan Lan
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorXiaomin Pang
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorYiming Li
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorCorresponding Author
Haiyan Liu
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Correspondence to: H. Y. Liu (E-mail: [email protected]) and L. G. Bai (E-mail: [email protected])Search for more papers by this authorHongyuan Yan
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
College of Public Health, Hebei University, Baoding 071002, China
Search for more papers by this authorCorresponding Author
Ligai Bai
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Correspondence to: H. Y. Liu (E-mail: [email protected]) and L. G. Bai (E-mail: [email protected])Search for more papers by this authorBin Guo
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorHuimin Wang
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorDanan Lan
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorXiaomin Pang
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorYiming Li
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Search for more papers by this authorCorresponding Author
Haiyan Liu
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Correspondence to: H. Y. Liu (E-mail: [email protected]) and L. G. Bai (E-mail: [email protected])Search for more papers by this authorHongyuan Yan
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
College of Public Health, Hebei University, Baoding 071002, China
Search for more papers by this authorCorresponding Author
Ligai Bai
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China
Correspondence to: H. Y. Liu (E-mail: [email protected]) and L. G. Bai (E-mail: [email protected])Search for more papers by this authorABSTRACT
Three temperature-sensitive monolithic columns were prepared by atom transfer radical polymerization and oxidation–reduction method using the initiator systems of CCl4/FeCl2, BPO/DMA, and APS/TEMED, respectively. The three monoliths were characterized by scanning electron microscopy, nitrogen adsorption, and thermogravimetric analysis. The obtained monolithic columns were used as on-line solid phase extraction sorbent coupled with high-performance liquid chromatography for the enrichment of β-sitosterol. By comparing some influencing factors on the adsorption, the optimum temperature-sensitive monolithic column which was initiated by CCl4/FeCl2 was selected for enrichment of β-sitosterol from plant oil. The maximum adsorption capacity of the monolith for β-sitosterol was 10.0031 mg/g. The limit of detection and limit of quantitation were 0.039 and 0.13 mg/mL, respectively. The recovery was in the range of 90.21–98.26%. The results showed that the monolith had better selectivity for β-sitosterol and could be used for enrichment of β-sitosterol in food samples. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47683.
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