Angewandte Chemie International Edition
Volume 64, Issue 28 e202512751
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Front Cover: Development of Organoautocatalyzed Double s-Bond C(sp2)-N Transamination Metathesis Reaction (Angew. Chem. Int. Ed. 28/2025)

Volker Klein, 

Volker Klein

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany

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Florian Schuster, 

Florian Schuster

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany

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Jonas Amthor, 

Jonas Amthor

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany

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Harald Maid, 

Harald Maid

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany

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Prabhakar Bijalwan, 

Prabhakar Bijalwan

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany

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Fahmi Himo, 

Fahmi Himo

Department of Organic Chemistry, Stockholm University, Stockholm, S-106 91 Sweden

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Stefano Santoro, 

Stefano Santoro

Department of Chemistry, Biology and Biotechnology, University of Perugia, Via Elce di Sotto 8, Perugia, 06123 Italy

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Svetlana B. Tsogoeva, 

Corresponding Author

Svetlana B. Tsogoeva

Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Nikolaus Fiebiger-Straße 10, 91058 Erlangen, Germany

E-mail: [email protected]

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First published: 26 June 2025
https://doi.org/10.1002/anie.202512751

Graphical Abstract

Organoautocatalyzed transamination metathesis of challenging cyclic tertiary amines is reported. In their Research Article (e202505275), Svetlana B. Tsogoeva and co-workers demonstrate the use of an in situ-formed pyrrolidinium salt as an efficient organoautocatalyst, enabling double C(sp2)-N bond metathesis at room temperature via a domino reaction mechanism. This metal- and additive-free transformation advances green, waste-reducing, and sustainable approaches in organic synthesis.

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