Volume 63, Issue 14 e202404234
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Inside Cover: Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity (Angew. Chem. Int. Ed. 14/2024)

Pengwen Chen

Pengwen Chen

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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Dr. Wenqian Yang

Dr. Wenqian Yang

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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Dr. Yuki Mochida

Dr. Yuki Mochida

Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki, 210-0821 Japan

Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 Japan

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Shangwei Li

Shangwei Li

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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Dr. Taehun Hong

Dr. Taehun Hong

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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Dr. Hiroaki Kinoh

Dr. Hiroaki Kinoh

Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki, 210-0821 Japan

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Prof. Dr. Kazunori Kataoka

Corresponding Author

Prof. Dr. Kazunori Kataoka

Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki, 210-0821 Japan

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Prof. Dr. Horacio Cabral

Corresponding Author

Prof. Dr. Horacio Cabral

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan

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First published: 18 March 2024

Graphical Abstract

Distinguish good from evil by selective endosomal escape. The nuanced endo/lysosomal activity of cathepsin B across cell types can act as a stimulus for cell-specific endosomal escape of proteins before degradation. In their Research Article (e202317817), Kazunori Kataoka, Horacio Cabral, et al. report nanocarriers leveraging on this differentiated cathepsin B activity to achieve cancer cell-specific delivery of antibodies. This innovative approach offers a new means for targeted intracellular delivery.

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