Enantiomeric NIR-II Emitting Rare-Earth-Doped Ag2Se Nanoparticles with Differentiated In Vivo Imaging Efficiencies
Qi Ding
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Resources (equal), Software (equal), Writing - original draft (equal)
Search for more papers by this authorDr. Jing Zhao
Department of Radiology, Jiangnan University, No. 1000, Hefeng Road, Wuxi, Jiangsu, 214122 China
Contribution: Funding acquisition (equal), Investigation (equal), Methodology (equal), Resources (equal), Software (equal), Visualization (equal)
Search for more papers by this authorDr. Hongyu Zhang
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Data curation (equal), Funding acquisition (equal), Investigation (equal), Methodology (equal), Project administration (equal), Resources (equal)
Search for more papers by this authorChen Li
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Resources (equal), Software (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorProf. Maozhong Sun
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Investigation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorChen Chen
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Methodology (equal), Project administration (equal), Resources (equal), Software (equal)
Search for more papers by this authorCorresponding Author
Prof. Hengwei Lin
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Funding acquisition (equal), Methodology (equal), Project administration (equal), Resources (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Chuanlai Xu
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorProf. Hua Kuang
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Liguang Xu
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Data curation (equal), Funding acquisition (equal), Supervision (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorQi Ding
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Resources (equal), Software (equal), Writing - original draft (equal)
Search for more papers by this authorDr. Jing Zhao
Department of Radiology, Jiangnan University, No. 1000, Hefeng Road, Wuxi, Jiangsu, 214122 China
Contribution: Funding acquisition (equal), Investigation (equal), Methodology (equal), Resources (equal), Software (equal), Visualization (equal)
Search for more papers by this authorDr. Hongyu Zhang
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Data curation (equal), Funding acquisition (equal), Investigation (equal), Methodology (equal), Project administration (equal), Resources (equal)
Search for more papers by this authorChen Li
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Resources (equal), Software (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorProf. Maozhong Sun
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Investigation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorChen Chen
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Methodology (equal), Project administration (equal), Resources (equal), Software (equal)
Search for more papers by this authorCorresponding Author
Prof. Hengwei Lin
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Funding acquisition (equal), Methodology (equal), Project administration (equal), Resources (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Chuanlai Xu
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorProf. Hua Kuang
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Prof. Liguang Xu
Key Laboratory of Synthetic and Biological Colloids, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
International Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122 P.R. China
Contribution: Conceptualization (equal), Data curation (equal), Funding acquisition (equal), Supervision (equal), Validation (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorGraphical Abstract
Chiral Ag2Se:Nd/Yd/Er NPs by introducing RuCl[(p-cymene(BINAP)]Cl as ligands were synthesized. Nd3+, Yb3+ and Er3+ as sensitizers case a fluorescence red-shift to 1550 nm with an intensity increased by 145.7-fold compared with Ag2Se:Nd/Yd/Er NPs. The fluorescence imaging efficiency of R-Ag2Se:Nd/Yd/Er NPs was 2-fold higher than that of S-Ag2Se:Nd/Yd/Er NPs.
Abstract
Here, chiral second near-infrared (NIR-II) emitting rare-earth doped silver selenide nanoparticles (R- or S-Ag2Se:Nd/Yd/Er NPs) were fabricated, exhibiting circular dichroism peak at 850 nm and fluorescence peak at 1550 nm, with 145.7-fold enhanced intensity compared to the reported Ag2Se NPs. Compared with S-Ag2Se:Nd/Yd/Er NPs, imaging efficiency of R-Ag2Se:Nd/Yd/Er NPs in living cells was significantly improved due to a higher cellular uptake rate and 927.7-fold higher affinity. Furthermore, R-Ag2Se:Nd/Yd/Er NPs reached at the tumor 2-fold faster than S type of NPs in vivo. We discover that chirality leads to differences in the affinity between chiral Ag2Se:Nd/Yd/Er NPs and cluster of differentiation 44 (CD44) onto the surface of murine mammary carcinoma cell to cause different in vivo imaging efficiency. These results reveal that chiral Ag2Se:Nd/Yd/Er NPs have high photoluminescence intensity and high in vivo imaging efficiency reflecting wide applications in biomedical diagnosis.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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