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Inside Back Cover: A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery (Angew. Chem. Int. Ed. 12/2020)
First published: 26 February 2020
Graphical Abstract
A coordinative dendrimer delivers 30 types of cargo proteins and peptides into the cytosol of living cells, while maintaining their bioactivity after intracellular release. In their Research Article on page 4711, Y. Cheng et al. report that dendrimers modified with a dipicolylamine/zinc(II) complex are capable of binding proteins through a combination of ionic and coordination interactions. This provides a new strategy to develop robust and efficient polymers for cytosolic protein delivery.
