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Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy
Dr. Xingshu Li,
Nahyun Kwon,
Tian Guo,
Prof. Zhuang Liu,
Prof. Juyoung Yoon,
Corresponding Author
Dr. Xingshu Li
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
These authors contributed equally to this work.
Search for more papers by this authorNahyun Kwon
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
These authors contributed equally to this work.
Search for more papers by this authorTian Guo
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Prof. Zhuang Liu
Institute of Functional Nano&Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123 China
Search for more papers by this authorCorresponding Author
Prof. Juyoung Yoon
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
Search for more papers by this authorDr. Xingshu Li,
Nahyun Kwon,
Tian Guo,
Prof. Zhuang Liu,
Prof. Juyoung Yoon,
Corresponding Author
Dr. Xingshu Li
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
These authors contributed equally to this work.
Search for more papers by this authorNahyun Kwon
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
These authors contributed equally to this work.
Search for more papers by this authorTian Guo
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Prof. Zhuang Liu
Institute of Functional Nano&Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123 China
Search for more papers by this authorCorresponding Author
Prof. Juyoung Yoon
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120–750 Korea
Search for more papers by this authorGraphical Abstract
PDT beats hypoxia: Novel and robust strategies, which can improve the therapeutic efficacy of photodynamic therapy (PDT) for hypoxic tumors, have been widely investigated in recent years. These efforts have led to the development of new approaches that have changed the paradigm of PDT and provided solutions to some key problems.
Abstract
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
Conflict of interest
The authors declare no conflict of interest.
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