Cover Picture: A Pyrene-Linked Cavity within a β-Barrel Protein Promotes an Asymmetric Diels–Alder Reaction (Angew. Chem. Int. Ed. 44/2017)
Graphical Abstract
A pyrene-linked protein cavity attracts two substrate molecules like the scent of a flower attracts butterflies. In their Communication on page 13618 ff., A. Onoda, T. Hayashi, and co-workers demonstrate that a polycyclic pyrene moiety linked within the rigid protein scaffold of the β-barrel of nitrobindin acts as a platform to provide an aromatic interaction with a substrate. An asymmetric Diels–Alder reaction between azachalcone and cyclopentadiene proceeds smoothly with high stereoselectivity within the reaction scaffold.
A pyrene-linked protein cavity attracts two substrate molecules like the scent of a flower attracts butterflies. In their Communication on page 13618 ff., A. Onoda, T. Hayashi, and co-workers demonstrate that a polycyclic pyrene moiety linked within the rigid protein scaffold of the β-barrel of nitrobindin acts as a platform to provide an aromatic interaction with a substrate. An asymmetric Diels–Alder reaction between azachalcone and cyclopentadiene proceeds smoothly with high stereoselectivity within the reaction scaffold.
NMR Spectroscopy
Light Olefins
Hydrogen Evolution Reaction
