Asymmetric Hydrogenation of Disubstituted Furans†
Jędrzej Wysocki
NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
Search for more papers by this authorDr. Nuria Ortega
Bayer Pharma AG, Medicinal Chemistry, Aprather Weg 18 A, 42113 Wuppertal (Germany)
Search for more papers by this authorCorresponding Author
Prof. Dr. Frank Glorius
NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/Search for more papers by this authorJędrzej Wysocki
NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
Search for more papers by this authorDr. Nuria Ortega
Bayer Pharma AG, Medicinal Chemistry, Aprather Weg 18 A, 42113 Wuppertal (Germany)
Search for more papers by this authorCorresponding Author
Prof. Dr. Frank Glorius
NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/Search for more papers by this authorWe thank Dr. Matthew N. Hopkinson for helpful discussions during preparation of this manuscript and Prof. Dr. Klaus Ditrich (BASF) for donation of precious chiral amines (ChiPros). This work was supported by the NRW Graduate School of Chemistry in Münster (J.W.).
Graphical Abstract
Pump it up! An asymmetric hydrogenation of disubstituted furans has been developed by using a Ru-NHC based catalyst system (NHC=N-heterocyclic carbene). This reaction converts flat furans into enantioenriched tetrahydrofurans of relevance in biology and material science.
Abstract
An enantioselective hydrogenation of disubstituted furans has been developed by using a chiral ruthenium catalyst with N-heterocyclic carbene ligands. This reaction converts furans into valuable enantioenriched disubstituted tetrahydrofurans.
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