Multiphase Intrafibrillar Mineralization of Collagen†
Dr. Li-na Niu
School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Search for more papers by this authorDr. Kai Jiao
School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Search for more papers by this authorDr. Heonjune Ryou
Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, Maryland, 21250 (USA)
Search for more papers by this authorDr. Cynthia K. Y. Yiu
Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong SAR (P.R. China)
Search for more papers by this authorCorresponding Author
Dr. Ji-hua Chen
School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Ji-hua Chen, School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Franklin R. Tay, School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Search for more papers by this authorDr. Lorenzo Breschi
Department of Medical Sciences, University of Trieste, Trieste; IGM, C.N.R.–IOR, Bologna (Italy)
Search for more papers by this authorDr. Dwayne D. Arola
Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, Maryland, 21250 (USA)
Search for more papers by this authorDr. David H. Pashley
School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Search for more papers by this authorCorresponding Author
Dr. Franklin R. Tay
School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Ji-hua Chen, School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Franklin R. Tay, School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Search for more papers by this authorDr. Li-na Niu
School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Search for more papers by this authorDr. Kai Jiao
School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Search for more papers by this authorDr. Heonjune Ryou
Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, Maryland, 21250 (USA)
Search for more papers by this authorDr. Cynthia K. Y. Yiu
Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong SAR (P.R. China)
Search for more papers by this authorCorresponding Author
Dr. Ji-hua Chen
School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Ji-hua Chen, School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Franklin R. Tay, School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Search for more papers by this authorDr. Lorenzo Breschi
Department of Medical Sciences, University of Trieste, Trieste; IGM, C.N.R.–IOR, Bologna (Italy)
Search for more papers by this authorDr. Dwayne D. Arola
Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, Maryland, 21250 (USA)
Search for more papers by this authorDr. David H. Pashley
School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Search for more papers by this authorCorresponding Author
Dr. Franklin R. Tay
School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Ji-hua Chen, School of Stomatology, Fourth Military Medical University, Xi'an (P.R. China)
Franklin R. Tay, School of Graduate Studies, Georgia Regents University, Augusta, GA 30912-1129 (USA)
Search for more papers by this authorThis research was supported by grant R01 DE015306-06 from NIDCR (to D.H.P.), ERA and IRRM awards from Georgia Health Sciences University (to F.R.T.), National Nature Science Foundation of China grant 81130078 (to J.H.C.), and National Key Basic Research Program of China grant 2012CB526704 (to J.H.C.). The murine mesenchymal stem cell line employed in this study was provided by the Texas A&M Health Science Center College of Medicine, Institute for Regenerative Medicine at Scott & White Hospital through grant P40-RR-017447 from the National Center for Research Resources, U.S. National Institutes of Health. We thank Frankie Chan from the University of Hong Kong for his help in STEM–EDX analysis.
Graphical Abstract
Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.
Supporting Information
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| Filename | Description |
|---|---|
| anie_201210259_sm_cl3d_projection.avi1.3 MB | cl3d_projection |
| anie_201210259_sm_micro_ct_1.avi3.2 MB | micro_ct_1 |
| anie_201210259_sm_miscellaneous_information.pdf2.3 MB | miscellaneous_information |
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