Trans-Platinum/Thiazole Complex Interferes with Sp1 Zinc-Finger Protein†
Siming Chen
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorDechen Xu
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorHuan Jiang
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorZhaoyong Xi
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorProf. Pingping Zhu
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorCorresponding Author
Prof. Yangzhong Liu
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874Search for more papers by this authorSiming Chen
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorDechen Xu
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorHuan Jiang
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorZhaoyong Xi
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorProf. Pingping Zhu
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
Search for more papers by this authorCorresponding Author
Prof. Yangzhong Liu
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874Search for more papers by this authorThis work was supported by the National Basic Research Program of China (973 Program, 2012CB932502, 2009CB918804), the National Science Foundation of China (21171156), and the Fundamental Research Funds for the Central Universities.
Graphical Abstract
No trafficking: The antitumor-active trans-platinum/thiazole complex trans-PtTz demonstrated high reactivity to the transcription factor Sp1, which is overexpressed in tumor cells. The binding of trans-PtTz disrupts the DNA interaction with Sp1 in vitro and prevents the protein trafficking from the cytoplasm into the nucleus (see picture).
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