Volume 47, Issue 40 pp. 7644-7647

Communication

Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor^†

Daniel Vomasta,

Daniel Vomasta

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg (Germany), Fax: (+49) 941-943-1717

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Christina Högner,

Christina Högner

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg (Germany), Fax: (+49) 941-943-1717

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Neil R. Branda Prof.,

Neil R. Branda Prof.

[email protected]

4D LABS at Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6 (Canada)

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Burkhard König Prof.,

Burkhard König Prof.

[email protected]

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg (Germany), Fax: (+49) 941-943-1717

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Daniel Vomasta,

Daniel Vomasta

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg (Germany), Fax: (+49) 941-943-1717

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Christina Högner,

Christina Högner

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg (Germany), Fax: (+49) 941-943-1717

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Neil R. Branda Prof.,

Neil R. Branda Prof.

[email protected]

4D LABS at Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6 (Canada)

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Burkhard König Prof.,

Burkhard König Prof.

[email protected]

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg (Germany), Fax: (+49) 941-943-1717

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First published: 22 September 2008

https://doi.org/10.1002/anie.200802242

Citations: 112

^†

This work was supported by the Deutsche Forschungsgemeinschaft, the Fonds der chemischen Industrie, the University of Regensburg, the Natural Sciences and Engineering Research Council of Canada, the Canada Research Chair Program, and Simon Fraser University.

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Graphical Abstract

Photoswitchable: The activity of a dithienylethene-based human carbonic anhydrase inhibitor (hCAI) can be regulated using light. Converting the flexible, ring-open isomer of the photoswitch into the rigid, ring-closed isomer using UV light reduces the inhibition and increases the activity of hCAI by 50-fold. The inhibitor can be turned back on by using visible light, which has many advantages in biological applications.

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September 22, 2008

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Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor^†

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Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor†

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Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor^†