Cross-Hybridization of Pyridinedicarboxamide Helical Strands and Their N-Oxides†
Chuanlang Zhan Dr.
Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-00-22-15
Search for more papers by this authorJean-Michel Léger Prof.
Laboratoire de Pharmacochimie, 146 rue Léo Saignat, 33076 Bordeaux, France
Search for more papers by this authorIvan Huc Dr.
Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-00-22-15
Search for more papers by this authorChuanlang Zhan Dr.
Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-00-22-15
Search for more papers by this authorJean-Michel Léger Prof.
Laboratoire de Pharmacochimie, 146 rue Léo Saignat, 33076 Bordeaux, France
Search for more papers by this authorIvan Huc Dr.
Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-00-22-15
Search for more papers by this authorThis work was supported by the CNRS, the University of Bordeaux I, the University of Bordeaux II, and by the French Ministry of Research and Education. We thank J. Lefeuvre for performing ab initio calculations.
Graphical Abstract
Swapping partners: The presence of N-oxide functions in double-helical dimers formed from oligo(pyridinecarboxamide)s promotes heterodimerization (see picture). This process mimicks the essence of base pairing and information storage in DNA through heterologous A/T and G/C Watson–Crick base pairing.
Supporting Information
Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600785_s.pdf or from the author.
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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