Formal Total Synthesis of (—)-Morphine by Cuprate Conjugate Addition†
Corresponding Author
Prof. Dr. Johann Mulzer
Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: Int. code +(1)313672280, e-mail: [email protected]
Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: Int. code +(1)313672280, e-mail: [email protected]Search for more papers by this authorDr. Gerd Dürner
Institut für Organische Chemie der Universität, Marie-Curie-Strasse 11, D-60439 Frankfurt am Main (Germany)
Search for more papers by this authorDipl.-Chem. Dirk Trauner
Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: Int. code +(1)313672280, e-mail: [email protected]
Search for more papers by this authorCorresponding Author
Prof. Dr. Johann Mulzer
Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: Int. code +(1)313672280, e-mail: [email protected]
Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: Int. code +(1)313672280, e-mail: [email protected]Search for more papers by this authorDr. Gerd Dürner
Institut für Organische Chemie der Universität, Marie-Curie-Strasse 11, D-60439 Frankfurt am Main (Germany)
Search for more papers by this authorDipl.-Chem. Dirk Trauner
Institut für Organische Chemie der Universität, Währingerstrasse 38, A-1090 Wien (Austria), Fax: Int. code +(1)313672280, e-mail: [email protected]
Search for more papers by this authorDedicated to Professor Wilhelm Fleischhacker on the occasion of his 65th birthday
Graphical Abstract
Conjugate addition of a vinyl cuprate to the sterically and electronically very demanding enone 1 is the key step of a short asymmetric total synthesis of (—)-dihydro-codeinone (2), an immediate precursor of (-)-morphine.
References
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