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1,5-Anhydrohexitol Nucleic Acids, a New Promising Antisense Construct^†

Corresponding Author

Dr. Arthur Aerschot Van

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]Search for more papers by this author

Dr. Ilse Verheggen,

Dr. Ilse Verheggen

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

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Dr. Chris Hendrix,

Dr. Chris Hendrix

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

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Prof. Dr. Piet Herdewijn,

Prof. Dr. Piet Herdewijn

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

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Dr. Arthur Aerschot Van,

Corresponding Author

Dr. Arthur Aerschot Van

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

Dr. Ilse Verheggen,

Dr. Ilse Verheggen

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

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Dr. Chris Hendrix,

Dr. Chris Hendrix

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

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Prof. Dr. Piet Herdewijn,

Prof. Dr. Piet Herdewijn

Laboratory of Medicinal Chemistry, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven (Belgium), Telefax: Int. code + (16)337340, e-mail: [email protected]

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First published: July 7, 1995

https://doi.org/10.1002/anie.199513381

Citations: 93

^†

This work was supported by a grant from the Fonds voor Geneeskunding Wetenschappelijk Onderzoek. A. V. A. is a Research Associate of the Belgian National Fund of Scientific Research. We thank Guido Schepers for his efficient technical assistance.

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Graphical Abstract

Both natural oligoribonucleotides and oligodeoxynucleotides are hybridized sequence-selectively by hexitol nucleic acids (HNA) 1, which are composed of 1,5-anhydrohexitol nucleoside analogues linked by phosphate groups. Owing to the strongly increased duplex stability, these constructs should be pursued for potential applications as antisense agents.

Abstract

For corrigendum see DOI:10.1002/anie.199521651

References

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Volume34, Issue12

July 7, 1995

Pages 1338-1339

1,5-Anhydrohexitol Nucleic Acids, a New Promising Antisense Construct^†

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1,5-Anhydrohexitol Nucleic Acids, a New Promising Antisense Construct†

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1,5-Anhydrohexitol Nucleic Acids, a New Promising Antisense Construct^†