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The First Chemical Partial Synthesis of the Nickel Complex of a Cobyrinic Acid Derivative^†^‡

Corresponding Author

Dipl.-Chem. Gerhard Holze

Institut de Chimie Organique de l'Université Pérolles, CH-1700 Friboug (Switzerland)

Institut de Chimie Organique de l'Université Pérolles, CH-1700 Friboug (Switzerland)Search for more papers by this author

Prof. Dr. Hans Herloff Inhoffen,

Prof. Dr. Hans Herloff Inhoffen

Fakultät für Chemie der Universität, D-7750 Konstanz (FRG)

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Dipl.-Chem. Gerhard Holze,

Corresponding Author

Dipl.-Chem. Gerhard Holze

Institut de Chimie Organique de l'Université Pérolles, CH-1700 Friboug (Switzerland)

Institut de Chimie Organique de l'Université Pérolles, CH-1700 Friboug (Switzerland)Search for more papers by this author

Prof. Dr. Hans Herloff Inhoffen,

Prof. Dr. Hans Herloff Inhoffen

Fakultät für Chemie der Universität, D-7750 Konstanz (FRG)

Search for more papers by this author

First published: October 1985

https://doi.org/10.1002/anie.198508671

Citations: 15

^†

We thank Professor Dr. A. Gossauer for support of this work.

^‡

Dedicated to Professor Albert Eschenmoser on the occasion of his 60th birthday

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The transmetalation of a vitamin B₁₂ building block was achieved as follows: oxidation of 1, NCo(CN)₂, to the seco compound, demetalation, reaction with Ni(ClO₄)₂, and recyclization at 100°C to give 1, MNiClO₄. Corrinoids of this kind, containing metal ions other than cobalt, were previously only accessible from natural metal-free corrinods or by total synthesis.

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Volume24, Issue10

October 1985

Pages 867-869

The First Chemical Partial Synthesis of the Nickel Complex of a Cobyrinic Acid Derivative^†^‡

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The First Chemical Partial Synthesis of the Nickel Complex of a Cobyrinic Acid Derivative^†^‡