Communication
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Pyrrolizidines by Rearrangement of β-Lactams†
†
Dedicated to Professor Rolf Sammet on the occasion of his 60th birthday
Graphical Abstract
1,5,5-Trifunctionalized pyrrolizidines are formed via ring expansion from the β-lactam (1) in the presence of NaOCH3. The action of acids produces the salt (2). Sterically uniform 1,5-pyrrolizidinedicarboxylic acid can be obtained from the ester (3).
